Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein and a member of LGI/epitempin family expressed in the peripheral nerve and interacts with ADAM22 and ADAM23 as well as syntaxin1 in the presynaptic SNARE complex. LGI3 is suggested to be involved in multiple functions. It induces neurite outgrowth and increases phosphorylation of the signal transduction proteins AKT and FAK (focal adhesion kinase) (Park et al. 2010). It appears to promote amyloid beta and synataxin1 endocytosis (Kimura et al. 2007, Okabayashi & Kimura 2008,2010).