LGI1 binds ADAM11

Stable Identifier
R-HSA-5682826
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
LGI1 binds ADAM11
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In addition to ADAM22 and ADAM23, LGI1 also binds to ADAM11 (Sagane et al. 2008). ADAM11 is essential for a proper neuronal function because ADAM11-deficient mice showed deficits in special learning, motor coordination and nociceptive response (Takahashi et al 2006a,b).

Literature References
PubMed ID Title Journal Year
18974846 LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11

Sugimoto, H, Sagane, K, Ishihama, Y

Int. J. Biol. Sci. 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
LGI1 binds ADAM11 (Canis familiaris)
LGI1 binds ADAM11 (Danio rerio)
LGI1 binds ADAM11 (Gallus gallus)
LGI1 binds ADAM11 (Mus musculus)
LGI1 binds ADAM11 (Rattus norvegicus)
LGI1 binds ADAM11 (Sus scrofa)
LGI1 binds ADAM11 (Xenopus tropicalis)
Authored
Garapati, P V  (2015-03-11)
Reviewed
Meijer, D  (2015-04-20)
Created
Garapati, P V  (2015-03-10)
Cite Us!