LGI1 binds ADAM11

Stable Identifier
R-HSA-5682826
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
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Summation

In addition to ADAM22 and ADAM23, LGI1 also binds to ADAM11 (Sagane et al. 2008). ADAM11 is essential for a proper neuronal function because ADAM11-deficient mice showed deficits in special learning, motor coordination and nociceptive response (Takahashi et al 2006a,b).

Literature References
PubMed ID Title Journal Year
18974846 LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11 Int. J. Biol. Sci. 2008
Participants
Input
Output
Participant Of
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Orthologous Events
LGI1 binds ADAM11 (Bos taurus)
LGI1 binds ADAM11 (Canis familiaris)
LGI1 binds ADAM11 (Danio rerio)
LGI1 binds ADAM11 (Drosophila melanogaster)
LGI1 binds ADAM11 (Gallus gallus)
LGI1 binds ADAM11 (Mus musculus)
LGI1 binds ADAM11 (Rattus norvegicus)
LGI1 binds ADAM11 (Sus scrofa)
LGI1 binds ADAM11 (Xenopus tropicalis)