K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]

Stable Identifier
R-HSA-5682847
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
K63PolyUb-K14,K16,p-S139-H2AFX, Ub,gamma-H2AX
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P16104 H2AX
Gene Names
H2AFX, H2AX
Chain
initiator methionine:1, chain:2-143
Reference Genes
BioGPS Gene:3014 H2AFX
COSMIC (genes):H2AFX H2AFX
CTD Gene:3014 H2AFX
dbSNP Gene:3014 H2AFX
ENSEMBL:ENSG00000188486 H2AFX
HGNC:4739 H2AFX
KEGG Gene (Homo sapiens):3014 H2AFX
Monarch:3014 H2AFX
NCBI Gene:3014 H2AFX
OMIM:601772 H2AFX
UCSC:P16104 H2AFX
Reference Transcript
Other Identifiers
0000060736
11754243_a_at
16745236
205436_s_at
212525_3p_s_at
212525_s_at
3014
3394184
3394185
3394186
3394187
3394188
3394189
3394190
40195_at
7952179
A_24_P38895
GE59719
GO:0000003
GO:0000077
GO:0000228
GO:0000724
GO:0000781
GO:0000785
GO:0000786
GO:0000790
GO:0000794
GO:0001673
GO:0001741
GO:0003674
GO:0003677
GO:0003684
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005813
GO:0005815
GO:0005856
GO:0006259
GO:0006281
GO:0006302
GO:0006303
GO:0006310
GO:0006325
GO:0006334
GO:0006342
GO:0006950
GO:0006974
GO:0007049
GO:0007283
GO:0007568
GO:0008150
GO:0009058
GO:0010212
GO:0016032
GO:0016607
GO:0019899
GO:0021987
GO:0022607
GO:0032991
GO:0034641
GO:0035861
GO:0042393
GO:0043226
GO:0044403
GO:0045739
GO:0046982
GO:0048856
GO:0051276
GO:0051321
GO:0065003
GO:0070062
GO:0071480
GO:0090398
GO:0090734
Hs.147097.1.A1_3p_a_at
ILMN_1785756
ILMN_2200331
PH_hs_0008797
PH_hs_0040597
TC11002362.hg
X14850_at
g4504252_3p_a_at
Participant Of
hasComponent
Other forms of this molecule
H2AFX [extracellular region]
Me2sR4-H2AFX [nucleoplasm]
p-S140-H2AFX [nucleoplasm]
p-S140,Y143-H2AFX [nucleoplasm]
p-Y143-H2AFX [nucleoplasm]
H2AFX [nucleoplasm]
Inferred To
phospho-h2ac14 [nucleoplasm] (Xenopus tropicalis)
phospho-K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Gallus gallus)
phospho-K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Xenopus tropicalis)
phospho-hta1 [nucleoplasm] (Schizosaccharomyces pombe)
phospho-htas-1 [nucleoplasm] (Caenorhabditis elegans)
phospho-LOC101735111 [nucleoplasm] (Xenopus tropicalis)
Homologues of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Danio rerio)
Homologues of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
Homologues of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
Homologues of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Xenopus tropicalis)
phospho-H2AX [nucleoplasm] (Canis familiaris)
phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
phospho-H2afx [nucleoplasm] (Rattus norvegicus)
Ghost homologue of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Sus scrofa)
phospho-si:ch211-113a14.19 [nucleoplasm] (Danio rerio)
phospho-h2ac12 [nucleoplasm] (Xenopus tropicalis)
phospho-h2afx.2 [nucleoplasm] (Xenopus tropicalis)
phospho-H2ax [nucleoplasm] (Mus musculus)
phospho-H2Av3 [nucleoplasm] (Dictyostelium discoideum)
phospho-h2ax [nucleoplasm] (Danio rerio)
phospho-ppard [nucleoplasm] (Xenopus tropicalis)
phospho-hta2 [nucleoplasm] (Schizosaccharomyces pombe)
phospho-H2Av1 [nucleoplasm] (Dictyostelium discoideum)
phospho-H2Av2 [nucleoplasm] (Dictyostelium discoideum)
Modified Residues
Name
O-phospho-L-serine at 140
Coordinate
140
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K63polyUb [nucleoplasm]) at 14
Coordinate
14
Modification
K63polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63polyUb [nucleoplasm]) at 16
Coordinate
16
Modification
K63polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
Target Pathogen
HPA
GeneCards
Ensembl
PRO
PDB
Interactors (18)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q14676 MDC1  6 0.965 21
 UniProt:O60934 NBN  3 0.859 14
 UniProt:P49959 MRE11  2 0.809 7
 UniProt:P62805 H4C1  19 0.802 5
 UniProt:P09874 PARP1  4 0.798 10
 UniProt:Q12888 TP53BP1  3 0.793 6
 UniProt:P38398 BRCA1  27 0.714 4
 UniProt:Q14191 WRN  2 0.667 6
 UniProt:P02545 LMNA  3 0.641 3
 UniProt:Q16695 H3-4  3 0.641 12
 UniProt:P63104 YWHAZ  2 0.577 6
 UniProt:O15297 PPM1D  1 0.544 3
 UniProt:P51532 SMARCA4  1 0.537 9
 UniProt:Q08945 SSRP1  1 0.527 2
 UniProt:Q9Y5B9 SUPT16H  1 0.527 2
 UniProt:Q92878 RAD50  1 0.527 3
 UniProt:P45983 MAPK8  3 0.524 3
 UniProt:Q13315 ATM  5 0.491 2
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