Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
LC3:ATG7 dimer binds ATG3
Stable Identifier
R-HSA-5682896
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
LC3:ATG7 dimer binds ATG3 (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The ATG7 dimer with bound LC3 binds ATG3. Deletion mutagenesis, biochemical data and modeling suggest that recruitment of ATG3 to the ATG7 N-terminal FAP domain results in presentation of the ATG3 active site to the LC3-ATG7 thioester linkage from the opposing monomer in the ATG7 dimer (Tanida et al. 2012, Klionsky & Schulman 2014). The activated LC3 protein is transferred to the E2-like enzyme ATG3 through a thioester bond (Ichimura et al. 2000).
Literature References
PubMed ID
Title
Journal
Year
22170151
The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation
Tanida, I
,
Komatsu, M
,
Yamasaki, M
,
Ueno, T
Autophagy
2012
Participants
Input
ATG3 [cytosol]
(Homo sapiens)
CysO572-ATG7-LC3:ATG7 [cytosol]
(Homo sapiens)
Output
CysO572-ATG7-LC3:ATG7:ATG3 [cytosol]
(Homo sapiens)
Participates
as an event of
Macroautophagy (Homo sapiens)
Orthologous Events
LC3:ATG7 dimer binds ATG3 (Bos taurus)
LC3:ATG7 dimer binds ATG3 (Caenorhabditis elegans)
LC3:ATG7 dimer binds ATG3 (Canis familiaris)
LC3:ATG7 dimer binds ATG3 (Dictyostelium discoideum)
LC3:ATG7 dimer binds ATG3 (Drosophila melanogaster)
LC3:ATG7 dimer binds ATG3 (Gallus gallus)
LC3:ATG7 dimer binds ATG3 (Mus musculus)
LC3:ATG7 dimer binds ATG3 (Plasmodium falciparum)
LC3:ATG7 dimer binds ATG3 (Rattus norvegicus)
LC3:ATG7 dimer binds ATG3 (Saccharomyces cerevisiae)
LC3:ATG7 dimer binds ATG3 (Schizosaccharomyces pombe)
LC3:ATG7 dimer binds ATG3 (Sus scrofa)
LC3:ATG7 dimer binds ATG3 (Xenopus tropicalis)
Authored
Jupe, S (2015-02-02)
Reviewed
Klionsky, DJ (2015-09-03)
Tooze, SA (2015-05-13)
Created
Jupe, S (2015-03-11)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text