KDM4A,B bind H4K20Me2

Stable Identifier
R-HSA-5682992
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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KDM4A,B bind H4K20Me2
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Histone demethylases KDM4A (JMJD2A) and KDM4B (JMJD2B) bind H4K20Me2 (Me2-K21-HIST1H4A) with a higher affinity than TP53BP1 (53BP1), thereby blocking TP53BP1 recruitment to DNA double-strand breaks (DSBs). Demethylation of HIST1H4A (histone H4) by KDM4A or KDM4B is not involved in the inhibition of TP53BP1 binding (Mallette et al. 2012).

Literature References
PubMed ID Title Journal Year
22373579 RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

Sixma, TK, Cui, G, Mer, G, Richard, S, Young, LC, Mallette, FA, Hendzel, MJ, Mattiroli, F

EMBO J. 2012
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Orthologous Events
KDM4A,B bind H4K20Me2 (Bos taurus)
KDM4A,B bind H4K20Me2 (Canis familiaris)
KDM4A,B bind H4K20Me2 (Danio rerio)
KDM4A,B bind H4K20Me2 (Mus musculus)
KDM4A,B bind H4K20Me2 (Rattus norvegicus)
KDM4A,B bind H4K20Me2 (Saccharomyces cerevisiae)
KDM4A,B bind H4K20Me2 (Schizosaccharomyces pombe)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-11)
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