PPP5C dephosphorylates TP53BP1

Stable Identifier
R-HSA-5683405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PPP5C-mediated dephosphorylation of TP53BP1 serine residues S25 and S1778 contributes to dissociation of TP53BP1 from DNA doubles strand break (DSB) sites and termination of DSB repair (Kang et al. 2009).

Literature References
PubMed ID Title Journal Year
19176521 Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage

Kang, Y, Lee, JH, Hoan, NN, Sohn, HM, Chang, IY, You, HJ

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PPP5C [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!