Reactome | PPP5C [nucleoplasm]

PPP5C [nucleoplasm]

Stable Identifier

R-HSA-5683410

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser for interactor UniProt:P31948 STIP1

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External Reference Information

External Reference

UniProt:P53041 PPP5C

Gene Names

PPP5C, PPP5

Chain

initiator methionine:1, chain:2-499

Reference Genes

BioGPS Gene:5536 PPP5C

COSMIC (genes):PPP5C PPP5C

CTD Gene:5536 PPP5C

dbSNP Gene:5536 PPP5C

ENSEMBL:ENSG00000011485 PPP5C

HGNC:9322 PPP5C

KEGG Gene (Homo sapiens):5536 PPP5C

Monarch:5536 PPP5C

NCBI Gene:5536 PPP5C

OMIM:600658 PPP5C

UCSC:P53041 PPP5C

Reference Transcript

RefSeq:NM_006247.3 PPP5C

Other Identifiers

0002470707

11718622_x_at

11745533_x_at

16863460

201979_s_at

3836763

3836764

3836772

3836774

3836779

3836781

3836784

3836786

3836787

3836789

3836790

3836791

3836794

3836795

3836796

3836797

3836798

3836799

3866044

391_at

392_g_at

5536

8029814

A_14_P136374

A_23_P153583

GE60120

GO:0000165

GO:0000278

GO:0001933

GO:0001965

GO:0003674

GO:0003723

GO:0004721

GO:0004722

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006259

GO:0006281

GO:0006302

GO:0006351

GO:0006464

GO:0006470

GO:0006950

GO:0006974

GO:0007049

GO:0007165

GO:0008017

GO:0008092

GO:0008150

GO:0008219

GO:0008289

GO:0009058

GO:0010288

GO:0016020

GO:0016576

GO:0016787

GO:0016791

GO:0031072

GO:0032991

GO:0034641

GO:0035970

GO:0042802

GO:0043005

GO:0043025

GO:0043123

GO:0043167

GO:0043204

GO:0043226

GO:0043231

GO:0043278

GO:0043531

GO:0044877

GO:0046872

GO:0048156

GO:0051276

GO:0051879

GO:0060548

GO:0070262

GO:0070301

GO:0071276

GO:0071944

GO:0101031

GO:0106306

GO:0106307

GO:1901215

GO:1904550

GO:1990635

GO:2000324

HMNXSV003006202

ILMN_1745332

PH_hs_0025229

TC19000663.hg

X89416_at

g5453957_3p_at

g5453957_3p_x_at

Participates

as a candidate of

TPR-containing co-chaperones [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PPP5C [cytosol]

Inferred To

PpD3 [nucleoplasm] (Drosophila melanogaster)

ppp5c [nucleoplasm] (Danio rerio)

ppp5c [nucleoplasm] (Xenopus tropicalis)

PPP5C [nucleoplasm] (Bos taurus)

PPP5C [nucleoplasm] (Canis familiaris)

PPP5C [nucleoplasm] (Dictyostelium discoideum)

PPP5C [nucleoplasm] (Sus scrofa)

ppt1 [nucleoplasm] (Schizosaccharomyces pombe)

Ppp5c [nucleoplasm] (Mus musculus)

Ppp5c [nucleoplasm] (Rattus norvegicus)

pph-5 [nucleoplasm] (Caenorhabditis elegans)

PPT1 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_006238.1

OpenTargets

ENSG00000011485

IntEnz

3.1.3.16

HPA

ENSG00000011485-PPP5C

GeneCards

P53041

ZINC target

P53041

Ensembl

ENSP00000012443, ENST00000012443, ENSG00000011485

PRO

P53041

Pharos - Targets

P53041

GlyGen

P53041

HMDB Protein

HMDBP08687

PDB

3H69, 3H60, 1WAO, 3H61, 5WG8, 3H62, 1S95, 3H63, 3H64, 2BUG, 4ZX2, 4ZVZ, 3H66, 3H67, 5HPE, 1A17, 5UI1, 3H68

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.867	8
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.834	12
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.708	5
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.625	4
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.623	4
UniProt:O14654 IRS4	2	p-Y-IRS4 [plasma membrane] (R-HSA-2424302) IRS4 [plasma membrane] (R-HSA-2424297)	0.569	3
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q9UHD1 CHRD1			0.547	2
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.539	3
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.527	6
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.527	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.524	3
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.508	4
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.499	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.499	2
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.499	3
UniProt:Q9H9G7 AGO3	1	EIF2C3 [cytosol] (R-HSA-210615)	0.499	2
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.499	2

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