Reactome | MAP1LC3B [autophagosome membrane]

MAP1LC3B [autophagosome membrane]

Stable Identifier

R-HSA-5683641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

autophagosome membrane

Synonyms

Microtubule-associated proteins 1A/1B light chain 3B, MLP3B_HUMAN

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External Reference Information

External Reference

UniProt:Q9GZQ8 MAP1LC3B

Gene Names

MAP1LC3B, MAP1ALC3

Chain

chain:1-120, propeptide:121-125

Reference Genes

BioGPS Gene:81631 MAP1LC3B

COSMIC (genes):MAP1LC3B MAP1LC3B

CTD Gene:81631 MAP1LC3B

dbSNP Gene:81631 MAP1LC3B

ENSEMBL:ENSG00000140941.14 MAP1LC3B

HGNC:13352 MAP1LC3B

KEGG Gene (Homo sapiens):81631 MAP1LC3B

Monarch:81631 MAP1LC3B

NCBI Gene:81631 MAP1LC3B

OMIM:609604 MAP1LC3B

UCSC:Q9GZQ8 MAP1LC3B

Reference Transcript

RefSeq:NM_022818.4 MAP1LC3B

Other Identifiers

0001990279

11731632_s_at

11738983_x_at

11738984_x_at

11748422_a_at

16821697

208785_PM_s_at

208785_s_at

208786_PM_s_at

208786_s_at

239845_PM_at

239845_at

3433487

3433489

3433491

3672823

3672825

3672829

3672831

3672832

3672838

3672841

3672843

3672844

3672845

3672846

39370_at

72361_at

7959023

7997740

81631

A_14_P132519

A_24_P108005

GE61704

GE79540

GE838028

GE893037

GO:0000045

GO:0000421

GO:0000422

GO:0000423

GO:0005515

GO:0005622

GO:0005737

GO:0005739

GO:0005773

GO:0005776

GO:0005829

GO:0005856

GO:0005874

GO:0005929

GO:0005930

GO:0006914

GO:0006995

GO:0007005

GO:0008017

GO:0008092

GO:0008289

GO:0009267

GO:0012505

GO:0016020

GO:0016236

GO:0031090

GO:0031410

GO:0031625

GO:0031966

GO:0043226

GO:0043231

GO:0097001

GO:0097352

HMNXSV003020216

Hs.224883.0.A1_3p_at

ILMN_1703244

PH_hs_0023988

TC16000674.hg

g9963772_3p_a_at

Participates

as a member of

as an output of

Other forms of this molecule

MAP1LC3B(2-121) [cytosol]

MAP1LC3B [cytosol]

Inferred To

Map1lc3b [autophagosome membrane] (Mus musculus)

Map1lc3b [autophagosome membrane] (Rattus norvegicus)

MAP1-LC3B [autophagosome membrane] (Danio rerio)

Homologues of MAP1LC3B [autophagosome membrane] (Dictyostelium discoideum)

lgg-2 [autophagosome membrane] (Caenorhabditis elegans)

MAP1LC3B [autophagosome membrane] (Bos taurus)

MAP1LC3B [autophagosome membrane] (Canis familiaris)

MAP1LC3B [autophagosome membrane] (Dictyostelium discoideum)

MAP1LC3B [autophagosome membrane] (Gallus gallus)

MAP1LC3B [autophagosome membrane] (Plasmodium falciparum)

MAP1LC3B [autophagosome membrane] (Sus scrofa)

MAP1LC3B [autophagosome membrane] (Xenopus tropicalis)

atg8 [autophagosome membrane] (Dictyostelium discoideum)

atg8 [autophagosome membrane] (Schizosaccharomyces pombe)

ATG8 [autophagosome membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_073729.1

OpenTargets

ENSG00000140941

GeneCards

Q9GZQ8

HPA

ENSG00000140941-MAP1LC3B

Ensembl

ENSP00000498476, ENST00000268607, ENSG00000140941, ENSP00000268607, ENST00000650688

PRO

Q9GZQ8

Pharos - Targets

Q9GZQ8

PDB

2ZJD, 6LAN, 4WAA, 3WAO, 3X0W, 5GMV, 1V49, 2LUE, 5XAE, 3VTU, 5DCN, 5MS6, 5XAD, 6J04, 5V4K, 3VTV, 5MS2, 5XAC, 2N9X, 7ELG, 5MS5, 5D94, 5W9A, 3VTW

Interactors (61)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.972	26
UniProt:Q9Y4P1 ATG4B	1	ATG4B [cytosol] (R-HSA-5671858)	0.949	14
UniProt:Q8IVP5 FUNDC1	4	p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.779	8
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.766	9
UniProt:Q9NT62 ATG3	8	ATG3 [cytosol] (R-HSA-5671860) CysO264-ATG3-MAP1LC3A [cytosol] (R-HSA-9819371) CysO264-ATG3-GABARAPL3 [cytosol] (R-HSA-5683569) CysO264-ATG3-MAP1LC3B [cytosol] (R-HSA-9819365) CysO264-ATG3-GABARAPL1 [cytosol] (R-HSA-9819381) CysO264-ATG3-MAP1LC3C [cytosol] (R-HSA-9819377) CysO264-ATG3-GABARAPL2 [cytosol] (R-HSA-9819376) CysO264-ATG3-GABARAP [cytosol] (R-HSA-9819379)	0.743	7
UniProt:O95352 ATG7	14	ATG7 [secretory granule lumen] (R-HSA-6801316) ATG7 [extracellular region] (R-HSA-6806451) ATG7 [ficolin-1-rich granule lumen] (R-HSA-6801293) ATG7(1-693)-BRAF(381-766) fusion [cytosol] (R-HSA-6802272) ATG7(1-693)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802517) CysO572-ATG7-MAP1LC3B [cytosol] (R-HSA-9820410) CysO572-ATG7-GARABAPL2 [cytosol] (R-HSA-9820413) CysO572-ATG7-GARABAP [cytosol] (R-HSA-9820417) CysO572-ATG7-GARABAPL1 [cytosol] (R-HSA-9820406) CysO572-ATG7-MAP1LC3C [cytosol] (R-HSA-9820407) CysO572-ATG7-MAP1LC3A [cytosol] (R-HSA-9820421) CysO572-ATG7-GARABAPL3 [cytosol] (R-HSA-9820420) ATG7 [cytosol] (R-HSA-947867) CysO572-ATG7 [cytosol] (R-HSA-5683584)	0.743	7
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.737	4
UniProt:O75143 ATG13	3	ATG13 [cytosol] (R-HSA-5333624) p-ATG13 [cytosol] (R-HSA-5675831) p-ATG13 [endoplasmic reticulum membrane] (R-HSA-8948049)	0.734	5
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.718	6
UniProt:Q8IZQ1 WDFY3			0.71	6
UniProt:Q64337	5	K7 ub-SQSTM1 [cytosol] (R-MMU-9759088) phospho-p-S349 SQSTM1 [cytosol] (R-MMU-9766524) phospho-ub K420 p-S349 SQSTM1 [cytosol] (R-MMU-9766536) SQSTM1 [nucleoplasm] (R-MMU-210961) SQSTM1 [cytosol] (R-MMU-193937)	0.698	6
UniProt:Q9BQS8 FYCO1			0.688	8
UniProt:Q8TD19 NEK9	3	p-T333-NEK9 [cytosol] (R-HSA-2530600) p-S29,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984213) p-S29,T210,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984225)	0.676	3
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.675	14
UniProt:Q9Y383 LC7L2			0.667	3
UniProt:Q9BQD3 KXDL1			0.666	4
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.666	4
UniProt:O75665 OFD1	1	OFD1 [cytosol] (R-HSA-380318)	0.664	7
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747)	0.656	3
UniProt:P46821 MAP1B			0.643	7
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.623	3
UniProt:Q9Z2F7	1	Bnip3l [mitochondrial outer membrane] (R-MMU-6798001)	0.611	5
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.602	5
UniProt:Q9UPU7 TBD2B			0.591	3
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.591	7
UniProt:Q8WWW0 RASF5			0.591	5
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(1-491) [cytosol] (R-HSA-2028280)	0.591	5
UniProt:Q01546 KRT76	1	KRT76 [cytosol] (R-HSA-6809633)	0.59	2
UniProt:Q8WZ42 TTN	2	TTN [extracellular region] (R-HSA-350729) TTN [cytosol] (R-HSA-350726)	0.59	4
UniProt:Q8NC44 RETR2			0.573	2
UniProt:P40344	8	ATG3 [cytosol] (R-SCE-5671860) CysO264-ATG3-MAP1LC3A [cytosol] (R-SCE-9819371) CysO264-ATG3-GABARAP [cytosol] (R-SCE-9819379) CysO264-ATG3-GABARAPL2 [cytosol] (R-SCE-9819376) CysO264-ATG3-MAP1LC3C [cytosol] (R-SCE-9819377) CysO264-ATG3-GABARAPL1 [cytosol] (R-SCE-9819381) CysO264-ATG3-MAP1LC3B [cytosol] (R-SCE-9819365) CysO264-ATG3-GABARAPL3 [cytosol] (R-SCE-5683569)	0.558	2
UniProt:P38862	12	ATG7 [cytosol] (R-SCE-947867) ATG7 [cytosol] (R-SCE-5683584) ATG7 [cytosol] (R-SCE-9820420) ATG7 [cytosol] (R-SCE-9820421) ATG7 [cytosol] (R-SCE-9820407) ATG7 [cytosol] (R-SCE-9820406) ATG7 [cytosol] (R-SCE-9820417) ATG7 [cytosol] (R-SCE-9820413) ATG7 [cytosol] (R-SCE-9820410) ATG7 [ficolin-1-rich granule lumen] (R-SCE-6801293) ATG7 [extracellular region] (R-SCE-6806451) ATG7 [secretory granule lumen] (R-SCE-6801316)	0.558	2
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:Q8WZA9 IRGQ			0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:O14576-2 O145762			0.556	3
UniProt:Q9BXM7 PINK1	4	PINK1 [mitochondrial outer membrane] (R-HSA-5205653) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628)	0.556	3
UniProt:P0DMV8 HSPA1A	4	HSPA1A [cytosol] (R-HSA-6792602) HSPA1A [nucleoplasm] (R-HSA-6792605) HSPA1A [extracellular region] (R-HSA-6805872) HSPA1A [ficolin-1-rich granule lumen] (R-HSA-6801496)	0.556	3
UniProt:O60260-5 PRKN			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:P05386 RPLP1	1	RPLP1 [cytosol] (R-HSA-72398)	0.547	2
UniProt:Q15424 SAFB	3	SAFB [nucleoplasm] (R-HSA-4085379) polySUMO2,3-K231,K294-SAFB [nucleoplasm] (R-HSA-4085357) monoSUMO1-K231,K294-SAFB [nucleoplasm] (R-HSA-4085343)	0.547	3
UniProt:Q9GZZ9 UBA5	1	UBA5 [cytosol] (R-HSA-947700)	0.544	2
UniProt:Q9NS23 RASF1			0.544	2
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.544	2
UniProt:O95210 STBD1	3	STBD1 [tertiary granule membrane] (R-HSA-6801484) STBD1 [plasma membrane] (R-HSA-6801561) STBD1 [ficolin-1-rich granule membrane] (R-HSA-6801519)	0.544	2
UniProt:Q86V97 KBTBD6	1	KBTBD6 [cytosol] (R-HSA-8863221)	0.544	2
UniProt:Q2TAZ0 ATG2A			0.544	2
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.544	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.544	2
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.527	2
UniProt:P78559 MAP1A			0.527	6
UniProt:Q676U5 ATG16L1	1	ATG16L1 [cytosol] (R-HSA-5671734)	0.525	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.525	4
UniProt:O75323 NIPSNAP2	1	NIPSNAP2 [cytosol] (R-HSA-9714668)	0.525	4
UniProt:Q9H1Y0 ATG5	3	ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [cytosol] (R-HSA-936010)	0.525	2
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.525	2
UniProt:Q14151 SAFB2			0.499	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.491	4

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