Reactome | MAP1LC3B [autophagosome membrane]

MAP1LC3B [autophagosome membrane]

Stable Identifier

R-HSA-5683641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

autophagosome membrane

Synonyms

Microtubule-associated proteins 1A/1B light chain 3B, MLP3B_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9GZQ8 MAP1LC3B

Gene Names

MAP1LC3B, MAP1ALC3

Chain

chain:1-120, propeptide:121-125

Reference Genes

BioGPS Gene:81631 MAP1LC3B

COSMIC (genes):MAP1LC3B MAP1LC3B

CTD Gene:81631 MAP1LC3B

dbSNP Gene:81631 MAP1LC3B

ENSEMBL:ENSG00000140941 MAP1LC3B

HGNC:13352 MAP1LC3B

KEGG Gene (Homo sapiens):81631 MAP1LC3B

Monarch:81631 MAP1LC3B

NCBI Gene:81631 MAP1LC3B

OMIM:609604 MAP1LC3B

UCSC:Q9GZQ8 MAP1LC3B

Reference Transcript

RefSeq:NM_022818.4 MAP1LC3B

Other Identifiers

0001990279

11731632_s_at

11738983_x_at

11738984_x_at

11748422_a_at

16821697

208785_s_at

208786_s_at

239845_at

3433487

3433489

3433491

3672823

3672825

3672829

3672831

3672832

3672838

3672841

3672843

3672844

3672845

3672846

39370_at

72361_at

7959023

7997740

81631

A_14_P132519

A_24_P108005

GE61704

GE79540

GE838028

GE893037

GO:0000045

GO:0000421

GO:0000422

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005773

GO:0005776

GO:0005829

GO:0005856

GO:0005874

GO:0005929

GO:0005930

GO:0006914

GO:0006950

GO:0006995

GO:0007005

GO:0008017

GO:0008092

GO:0008150

GO:0009056

GO:0009267

GO:0012505

GO:0016020

GO:0016236

GO:0019899

GO:0022607

GO:0031090

GO:0031410

GO:0031625

GO:0043226

GO:0043231

GO:0097352

Hs.224883.0.A1_3p_at

ILMN_1703244

PH_hs_0023988

TC16000674.hg

g9963772_3p_a_at

Participant Of

hasMember

output

Enhanced autophagosome formation

Other forms of this molecule

MAP1LC3B [cytosol]

MAP1LC3B(2-121) [cytosol]

Inferred To

Map1lc3b [autophagosome membrane] (Mus musculus)

Map1lc3b [autophagosome membrane] (Rattus norvegicus)

Homologues of MAP1LC3B [autophagosome membrane] (Dictyostelium discoideum)

lgg-2 [autophagosome membrane] (Caenorhabditis elegans)

MAP1LC3B [autophagosome membrane] (Bos taurus)

MAP1LC3B [autophagosome membrane] (Canis familiaris)

MAP1LC3B [autophagosome membrane] (Dictyostelium discoideum)

MAP1LC3B [autophagosome membrane] (Gallus gallus)

MAP1LC3B [autophagosome membrane] (Plasmodium falciparum)

MAP1LC3B [autophagosome membrane] (Sus scrofa)

MAP1LC3B [autophagosome membrane] (Xenopus tropicalis)

map1lc3b [autophagosome membrane] (Danio rerio)

atg8 [autophagosome membrane] (Dictyostelium discoideum)

atg8 [autophagosome membrane] (Schizosaccharomyces pombe)

ATG8 [autophagosome membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_073729.1

OpenTargets

ENSG00000140941

HPA

ENSG00000140941-MAP1LC3B

GeneCards

Q9GZQ8

Ensembl

ENSP00000498476, ENST00000650688, ENSP00000268607, ENST00000268607, ENSG00000140941

PRO

Q9GZQ8

PDB

5XAD, 6J04, 2ZJD, 5DCN, 3X0W, 3WAO, 5MS6, 5W9A, 5XAC, 4WAA, 5V4K, 3VTW, 5MS5, 3VTU, 2LUE, 5XAE, 5D94, 5GMV, 2N9X, 5MS2, 3VTV, 1V49

Interactors (57)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13501 SQSTM1	2	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961)	0.97	24
UniProt:Q9Y4P1 ATG4B	1	ATG4B [cytosol] (R-HSA-5671858)	0.953	14
UniProt:Q8IVP5 FUNDC1	4	p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.779	8
UniProt:Q9NT62 ATG3	2	CysO263-ATG3 [cytosol] (R-HSA-5683569) ATG3 [cytosol] (R-HSA-5671860)	0.77	7
UniProt:O95352 ATG7	7	ATG7 [cytosol] (R-HSA-947867) ATG7 [ficolin-1-rich granule lumen] (R-HSA-6801293) CysO572-ATG7 [cytosol] (R-HSA-5683584) p-ATG7-BRAF fusion [cytosol] (R-HSA-6802517) ATG7-BRAF fusion [cytosol] (R-HSA-6802272) ATG7 [secretory granule lumen] (R-HSA-6801316) ATG7 [extracellular region] (R-HSA-6806451)	0.77	7
UniProt:Q14596 NBR1	2	NBR1 [cytosol] (R-HSA-9665180) NBR1 [peroxisomal membrane] (R-HSA-9665177)	0.766	9
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.737	4
UniProt:O75143 ATG13	3	p-ATG13 [cytosol] (R-HSA-5675831) ATG13 [cytosol] (R-HSA-5333624) p-ATG13 [endoplasmic reticulum membrane] (R-HSA-8948049)	0.734	5
UniProt:Q9BQS8 FYCO1			0.718	8
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.718	6
UniProt:Q8IZQ1 WDFY3			0.71	6
UniProt:P46821 MAP1B			0.708	7
UniProt:Q64337	2	Sqstm1 [cytosol] (R-MMU-193937) Sqstm1 [nucleoplasm] (R-MMU-210961)	0.698	6
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.675	14
UniProt:Q9Y383 LC7L2			0.667	3
UniProt:Q9BQD3 KXDL1			0.666	4
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.666	4
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [recycling endosome] (R-HSA-8854761) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131)	0.656	3
UniProt:Q13188 STK3	4	p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696)	0.632	5
UniProt:Q8WWW0 RASF5			0.632	5
UniProt:Q13043 STK4	4	p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) STK4(327-487) [cytosol] (R-HSA-2028668) STK4(1-487) [cytosol] (R-HSA-201627)	0.632	7
UniProt:P78559 MAP1A			0.623	6
UniProt:Q9Z2F7	1	Bnip3l [mitochondrial outer membrane] (R-MMU-6798001)	0.611	5
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.602	5
UniProt:Q9UPU7 TBD2B			0.591	3
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.591	4
UniProt:O75323 NIPS2			0.591	4
UniProt:Q8NC44 RETR2			0.573	2
UniProt:Q14145 KEAP1	2	KEAP1 [cytosol] (R-HSA-976038) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.564	2
UniProt:P40344	2	ATG3 [cytosol] (R-SCE-5683569) ATG3 [cytosol] (R-SCE-5671860)	0.558	2
UniProt:P38862	5	ATG7 [extracellular region] (R-SCE-6806451) ATG7 [ficolin-1-rich granule lumen] (R-SCE-6801293) ATG7 [secretory granule lumen] (R-SCE-6801316) ATG7 [cytosol] (R-SCE-5683584) ATG7 [cytosol] (R-SCE-947867)	0.558	2
UniProt:Q8WZA9 IRGQ			0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:Q9BXM7 PINK1	4	PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [mitochondrial outer membrane] (R-HSA-5205653)	0.556	3
UniProt:P05386 RPLP1	1	RPLP1 [cytosol] (R-HSA-72398)	0.547	2
UniProt:Q15424 SAFB	3	SUMO2,3-K231,K294-SAFB [nucleoplasm] (R-HSA-4085357) SAFB [nucleoplasm] (R-HSA-4085379) SUMO1-K231,K294-SAFB [nucleoplasm] (R-HSA-4085343)	0.547	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.544	2
UniProt:Q676U5 ATG16L1	1	ATG16L1 [cytosol] (R-HSA-5671734)	0.544	2
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.544	2
UniProt:Q9GZZ9 UBA5	1	UBA5 [cytosol] (R-HSA-947700)	0.544	2
UniProt:Q9NS23 RASF1			0.544	2
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.544	2
UniProt:O95210 STBD1	3	STBD1 [plasma membrane] (R-HSA-6801561) STBD1 [ficolin-1-rich granule membrane] (R-HSA-6801519) STBD1 [tertiary granule membrane] (R-HSA-6801484)	0.544	2
UniProt:Q86V97 KBTBD6	1	KBTBD6 [cytosol] (R-HSA-8863221)	0.544	2
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.544	2
UniProt:Q2TAZ0 ATG2A			0.544	2
UniProt:Q8TD19 NEK9	3	p-S29,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984213) p-T333-NEK9 [cytosol] (R-HSA-2530600) p-S29,T210,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984225)	0.544	2
UniProt:Q9H1Y0 ATG5	3	GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) ATG5 [cytosol] (R-HSA-936010)	0.544	2
UniProt:Q14151 SAFB2			0.499	3
UniProt:Q9NX00 TM160			0.499	4
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.499	3
UniProt:O75665 OFD1	1	OFD1 [cytosol] (R-HSA-380318)	0.499	4
UniProt:Q9H492 MAP1LC3A	3	MAP1LC3A(1-121) [cytosol] (R-HSA-5682681) MAP1LC3A [cytosol] (R-HSA-5205676) MAP1LC3A [autophagosome membrane] (R-HSA-5683640)	0.499	2
UniProt:Q9BPW8 NIPS1			0.499	2
UniProt:P55084 HADHB	1	HADHB [mitochondrial inner membrane] (R-HSA-77266)	0.499	2
UniProt:P41743 PRKCI	3	PRKCI [cytosol] (R-HSA-58206) PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [plasma membrane] (R-HSA-420005)	0.499	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.491	4

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