Reactome | MAP1LC3B [autophagosome membrane]

MAP1LC3B [autophagosome membrane]

Stable Identifier

R-HSA-5683641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

autophagosome membrane

Synonyms

Microtubule-associated proteins 1A/1B light chain 3B, MLP3B_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9GZQ8 MAP1LC3B

Gene Names

MAP1LC3B, MAP1ALC3

Chain

chain:1-120, propeptide:121-125

Reference Genes

BioGPS Gene:81631 MAP1LC3B

COSMIC (genes):MAP1LC3B MAP1LC3B

CTD Gene:81631 MAP1LC3B

dbSNP Gene:81631 MAP1LC3B

ENSEMBL:ENSG00000140941 MAP1LC3B

HGNC:13352 MAP1LC3B

KEGG Gene (Homo sapiens):81631 MAP1LC3B

Monarch:81631 MAP1LC3B

NCBI Gene:81631 MAP1LC3B

OMIM:609604 MAP1LC3B

UCSC:Q9GZQ8 MAP1LC3B

Reference Transcript

RefSeq:NM_022818.4 MAP1LC3B

Other Identifiers

0001990279

11738983_x_at

11738984_x_at

11748422_a_at

16821697

1V49

208785_s_at

208786_s_at

239845_at

2LUE

2N9X

2ZJD

3433487

3433489

3433491

3672829

3672831

3672832

3672838

3672841

3672843

3672844

3672845

3672846

37216

39370_at

3VTU

3VTV

3VTW

3WAO

3X0W

4WAA

52474

52484

53767

5D94

5DCN

5GMV

5MS2

5MS5

5MS6

5V4K

5W9A

5XAC

5XAD

5XAE

72361_at

7959023

7997740

81631

A_14_P132519

A_24_P108005

AAG09686

AAG23182

AAH18634

AAH41874

AAH67797

AAM10499

AF087871

AF183417

AF303888

AK025556

AK290956

AL834298

BAB15169

BAF83645

BC018634

BC041874

BC067797

CAB037216

CAD38970

CCDS10960

CH471114

DKFZp762B153

EAW95394

EAW95398

ENSG00000140941

ENSP00000268607

ENST00000268607

ENST00000268607.9

EntrezGene:81631

EntrezGene:MAP1LC3B

g9963772_3p_a_at

GE61704

GE79540

GE838028

GO:0000045

GO:0000421

GO:0000422

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005773

GO:0005776

GO:0005829

GO:0005856

GO:0005874

GO:0005929

GO:0005930

GO:0006914

GO:0006950

GO:0006995

GO:0007005

GO:0008017

GO:0008092

GO:0008150

GO:0009056

GO:0009267

GO:0012505

GO:0016020

GO:0016236

GO:0019899

GO:0022607

GO:0031090

GO:0031410

GO:0031625

GO:0043226

GO:0097352

H3BM99

H3BTE7

H3BTL1

HGNC:13352

HPA052474

HPA052484

HPA053767

Hs.224883.0.A1_3p_at

ILMN_1703244

IPR004241

IPR029071

MAP1LC3B

MAP1LC3B-201

MIM:609604

NM_022818

NP_073729

PF02991

PH_hs_0023988

Q658J6

TC16000674.hg

UPI0000001057

Participant Of

hasMember

Other forms of this molecule

MAP1LC3B [cytosol]

MAP1LC3B(2-121) [cytosol]

Inferred To

Homologues of MAP1LC3B [autophagosome membrane] (Dictyostelium discoideum)

MAP1LC3B [autophagosome membrane] (Bos taurus)

MAP1LC3B [autophagosome membrane] (Caenorhabditis elegans)

MAP1LC3B [autophagosome membrane] (Canis familiaris)

MAP1LC3B [autophagosome membrane] (Danio rerio)

MAP1LC3B [autophagosome membrane] (Dictyostelium discoideum)

MAP1LC3B [autophagosome membrane] (Gallus gallus)

MAP1LC3B [autophagosome membrane] (Mus musculus)

MAP1LC3B [autophagosome membrane] (Plasmodium falciparum)

MAP1LC3B [autophagosome membrane] (Rattus norvegicus)

MAP1LC3B [autophagosome membrane] (Saccharomyces cerevisiae)

MAP1LC3B [autophagosome membrane] (Schizosaccharomyces pombe)

MAP1LC3B [autophagosome membrane] (Sus scrofa)

MAP1LC3B [autophagosome membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_073729.1

OpenTargets

ENSG00000140941

GeneCards

Q9GZQ8

PRO

Q9GZQ8

PDB

2ZJD, 5D94, 5MS2, 5GMV, 3VTW, 5MS5, 5XAE, 3VTV, 5V4K, 5DCN, 3X0W, 5XAD, 3WAO, 4WAA, 3VTU, 5W9A, 2LUE, 5MS6, 5XAC, 1V49, 2N9X

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13501 SQSTM1	2	SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.968	23
UniProt:Q8IVP5 FUNDC1	4	p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.779	8
UniProt:Q9NT62 ATG3	2	ATG3 [cytosol] (R-HSA-5671860) CysO263-ATG3 [cytosol] (R-HSA-5683569)	0.77	7
UniProt:Q64337	2	SQSTM1 [cytosol] (R-MMU-193937) SQSTM1 [nucleoplasm] (R-MMU-210961)	0.698	6
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.675	14
UniProt:O75385 ULK1	7	ULK1 [mitochondrial outer membrane] (R-HSA-8948145) ULK1 [cytosol] (R-HSA-1632847) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) ULK1 [recycling endosome] (R-HSA-8854761)	0.656	3
UniProt:Q13188 STK3	4	STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684)	0.632	5
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) STK4(327-487) [cytosol] (R-HSA-2028668)	0.632	7
UniProt:Q9Z2F7	1	BNIP3L [mitochondrial outer membrane] (R-MMU-6798001)	0.611	5
UniProt:P35222 CTNNB1	24	CTNNB1 S45P [cytosol] (R-HSA-4791272) CTNNB1 S45F [cytosol] (R-HSA-4791268) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [plasma membrane] (R-HSA-9038440) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.602	5
UniProt:P40344	2	ATG3 [cytosol] (R-SCE-5671860) CysO263-ATG3 [cytosol] (R-SCE-5683569)	0.558	2
UniProt:Q9BXM7 PINK1	4	PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [mitochondrial outer membrane] (R-HSA-5205653)	0.556	3
UniProt:Q15424 SAFB	3	SUMO2,3-K231,K294-SAFB [nucleoplasm] (R-HSA-4085357) SAFB [nucleoplasm] (R-HSA-4085379) SUMO1-K231,K294-SAFB [nucleoplasm] (R-HSA-4085343)	0.547	3
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.544	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.544	2
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.544	2
UniProt:Q9H1Y0 ATG5	3	GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) ATG5 [cytosol] (R-HSA-936010)	0.544	2
UniProt:Q676U5 ATG16L1	1	ATG16L1 [cytosol] (R-HSA-5671734)	0.544	2
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.544	2
UniProt:P41743 PRKCI	3	PRKCI [cytosol] (R-HSA-58206) PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [plasma membrane] (R-HSA-420005)	0.499	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.491	4