Reactome | SFTPC [lamellar body]

SFTPC [lamellar body]

Stable Identifier

R-HSA-5683717

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lamellar body

Synonyms

Pulmonary surfactant-associated protein C, PSPC_HUMAN

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External Reference Information

External Reference

UniProt:P11686 SFTPC

Gene Names

SFTPC, SFTP2

Chain

propeptide:1-23, chain:24-58, propeptide:59-197

Reference Genes

BioGPS Gene:6440 SFTPC

COSMIC (genes):SFTPC SFTPC

CTD Gene:6440 SFTPC

dbSNP Gene:6440 SFTPC

ENSEMBL:ENSG00000168484 SFTPC

ENSEMBL_homo_sapiens_GENE:ENSG00000168484.13 SFTPC

HGNC:10802 SFTPC

KEGG Gene (Homo sapiens):6440 SFTPC

Monarch:6440 SFTPC

NCBI Gene:6440 SFTPC

OMIM:178620 SFTPC

UCSC:P11686 SFTPC

Reference Transcript

Other Identifiers

11754641_x_at

11757270_x_at

11763961_x_at

11764024_x_at

205982_3p_x_at

205982_PM_x_at

205982_x_at

211735_PM_x_at

211735_x_at

214387_PM_x_at

214387_x_at

3089201

3089202

3089203

3089205

3089206

3089207

3089208

3089211

3089213

3089214

38691_PM_s_at

38691_s_at

6440

8145047

A_14_P129555

A_23_P95213

A_24_P250666

GE81223

GO:0005515

GO:0005576

GO:0005615

GO:0005768

GO:0005783

GO:0005789

GO:0007585

GO:0016020

GO:0031410

GO:0042599

GO:0042802

GO:0043226

GO:0045334

GO:0097208

GO:0097486

HMNXSV003008852

Hs.1074.1.A1_3p_s_at

Hs.1074.3.A1_3p_s_at

ILMN_2206949

PH_hs_0000140

g13543508_3p_s_at

g4506906_3p_s_at

g4506906_3p_x_at

Participates

as an output of

SFTPB dimer,C translocate from multivesicle body to lamellar body (Homo sapiens)

as an input of

SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Homo sapiens)

Other forms of this molecule

pro-SFTPC P115L [endoplasmic reticulum membrane]

pro-SFTPC P30L [endoplasmic reticulum membrane]

pro-SFTPC [endoplasmic reticulum membrane]

pro-SFTPC [multivesicular body lumen]

SFTPC [extracellular region]

SFTPC [clathrin-coated endocytic vesicle]

SFTPC(24-58) [multivesicular body lumen]

SFTPC(59-197) [multivesicular body lumen]

Inferred To

Sftpc [lamellar body] (Mus musculus)

Sftpc [lamellar body] (Rattus norvegicus)

SFTPC [lamellar body] (Bos taurus)

SFTPC [lamellar body] (Canis familiaris)

SFTPC [lamellar body] (Gallus gallus)

SFTPC [lamellar body] (Sus scrofa)

Cross References

RefSeq

NP_001304708.1, NP_003009.2, NP_001165828.1, NP_001165881.1, NP_001304707.1, NP_001304709.1

OpenTargets

ENSG00000168484

GeneCards

P11686

HPA

ENSG00000168484-SFTPC

Ensembl

ENSG00000168484, ENSP00000316152, ENST00000318561

PRO

P11686

Pharos - Targets

P11686

Orphanet

15279

PDB

2YAD

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BSE2 TMM79			0.901	15
UniProt:P11686 SFTPC	9	pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.83	8
UniProt:Q07325 CXCL9	1	CXCL9 [extracellular region] (R-HSA-373856)	0.781	7
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560)	0.718	6
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.666	4
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.666	4
UniProt:Q9BZL3 SMIM3			0.601	4
UniProt:Q8N205-2 SYNE4			0.601	4
UniProt:Q3MIR4 CC50B			0.556	3
UniProt:Q8N112 LSME2			0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q8TBE3 FNDC9			0.556	3
UniProt:P15941-11 MUC1			0.556	3
UniProt:P48165 GJA8	1	GJA8 [endoplasmic reticulum membrane] (R-HSA-190702)	0.556	3
UniProt:Q8IV31 TM139			0.556	3
UniProt:Q8TD46-4 CD200R1			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:P05981 HPN	2	HPN(163-417) [plasma membrane] (R-HSA-8849219) HPN(1-162) [plasma membrane] (R-HSA-6800195)	0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:P38484 IFNGR2	1	IFNGR2 [plasma membrane] (R-HSA-629620)	0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:J3KQ12 J3KQ12			0.556	3
UniProt:P60059 SEC61G	3	SEC61G [phagocytic vesicle membrane] (R-HSA-1236798) SEC61G [endoplasmic reticulum membrane] (R-HSA-265003) SEC61G [cytosol] (R-HSA-5250558)	0.556	3
UniProt:P32942 ICAM3	1	ICAM3 [plasma membrane] (R-HSA-197682)	0.556	3
UniProt:Q9BVX2 T106C			0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:O15393-2 TMPRSS2			0.556	3
UniProt:Q9Y336 SIGLEC9	2	SIGLEC9 [plasma membrane] (R-HSA-197723) SIGLEC9 [secretory granule membrane] (R-HSA-6804775)	0.556	3
UniProt:O43889-2 CREB3			0.556	3
UniProt:Q8N205 SYNE4			0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [cell junction] (R-HSA-421264) CLDN5 [plasma membrane] (R-HSA-419991)	0.556	3

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