Reactome | CHEK2 is recruited to DNA DSBs

CHEK2 is recruited to DNA DSBs

Stable Identifier

R-HSA-5683735

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Summation

CHEK2 (CHK2, Cds1) is recruited to DNA double strand breaks (DSBs) mainly through its interaction with TP53BP1 (53BP1) (Wang et al. 2002), but BRCA1 also contributes to CHEK2 recruitment (Wilson and Stern 2008).

Literature References

PubMed ID	Title	Journal	Year
19001859	NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway	Cell Cycle	2008
12364621	53BP1, a mediator of the DNA damage checkpoint.	Science	2002

Participants

Input

Output

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

Orthologous Events

CHEK2 is recruited to DNA DSBs (Bos taurus)

CHEK2 is recruited to DNA DSBs (Canis familiaris)

CHEK2 is recruited to DNA DSBs (Danio rerio)

CHEK2 is recruited to DNA DSBs (Gallus gallus)

CHEK2 is recruited to DNA DSBs (Mus musculus)

CHEK2 is recruited to DNA DSBs (Rattus norvegicus)

CHEK2 is recruited to DNA DSBs (Sus scrofa)

CHEK2 is recruited to DNA DSBs (Taeniopygia guttata)

CHEK2 is recruited to DNA DSBs (Xenopus tropicalis)