CHEK2 is recruited to DNA DSBs

Stable Identifier
R-HSA-5683735
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CHEK2 (CHK2, Cds1) is recruited to DNA double strand breaks (DSBs) mainly through its interaction with TP53BP1 (53BP1) (Wang et al. 2002), but BRCA1 also contributes to CHEK2 recruitment (Wilson and Stern 2008).

Literature References
Participants
Participant Of
Orthologous Events