Reactome | CHEK2 is recruited to DNA DSBs

CHEK2 is recruited to DNA DSBs

Stable Identifier

R-HSA-5683735

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CHEK2 (CHK2, Cds1) is recruited to DNA double-strand breaks (DSBs) mainly through its interaction with TP53BP1 (53BP1) (Wang et al. 2002), but BRCA1 also contributes to CHEK2 recruitment (Wilson and Stern 2008).

Literature References

PubMed ID	Title	Journal	Year
12364621	53BP1, a mediator of the DNA damage checkpoint. Elledge, SJ, Carpenter, PB, Wang, B, Matsuoka, S	Science	2002
19001859	NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway Stern, DF, Wilson, KA	Cell Cycle	2008