Reactome | TRAPPC3 [cytosol]

TRAPPC3 [cytosol]

Stable Identifier

R-HSA-5683761

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BET3, TRAPP1, TRAPP2, TRAPP3, TRAPP core

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
      - TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)
        
        TRAPPCs [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)
        
        TRAPPCIII [cytosol] (Homo sapiens)
        
        TRAPPC3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43617 TRAPPC3

Gene Names

TRAPPC3, BET3, CDABP0066

Chain

chain:1-180

Reference Genes

BioGPS Gene:27095 TRAPPC3

COSMIC (genes):TRAPPC3 TRAPPC3

CTD Gene:27095 TRAPPC3

dbSNP Gene:27095 TRAPPC3

ENSEMBL:ENSG00000054116 TRAPPC3

ENSEMBL_homo_sapiens_GENE:ENSG00000054116.12 TRAPPC3

HGNC:19942 TRAPPC3

KEGG Gene (Homo sapiens):27095 TRAPPC3

Monarch:27095 TRAPPC3

NCBI Gene:27095 TRAPPC3

OMIM:610955 TRAPPC3

UCSC:O43617 TRAPPC3

Reference Transcript

Other Identifiers

11728222_a_at

16685208

203511_PM_s_at

203511_s_at

203512_PM_at

203512_at

2406598

2406599

2406600

2406601

2406603

2406608

2406609

2406614

2406615

2406616

2406617

27095

34705_at

7914887

A_23_P200535

GE55248

GO:0000139

GO:0005515

GO:0005737

GO:0005768

GO:0005783

GO:0005794

GO:0005829

GO:0006888

GO:0006891

GO:0006901

GO:0016192

GO:0030008

GO:0031410

GO:0033106

GO:0043226

GO:0048193

GO:0048208

GO:0061024

GO:0065003

GO:0099022

GO:1990071

GO:1990072

HMNXSV003008556

ILMN_1751627

PH_hs_0014934

TC01002504.hg

g2791803_3p_a_at

g7656925_3p_at

Participates

as a component of

Inferred To

Bet3 [cytosol] (Drosophila melanogaster)

Trappc3 [cytosol] (Mus musculus)

Trappc3 [cytosol] (Rattus norvegicus)

trpp-3 [cytosol] (Caenorhabditis elegans)

trappc3 [cytosol] (Dictyostelium discoideum)

trappc3 [cytosol] (Xenopus tropicalis)

bet3 [cytosol] (Schizosaccharomyces pombe)

TRAPPC3 [cytosol] (Bos taurus)

TRAPPC3 [cytosol] (Canis familiaris)

TRAPPC3 [cytosol] (Gallus gallus)

TRAPPC3 [cytosol] (Plasmodium falciparum)

TRAPPC3 [cytosol] (Sus scrofa)

zgc:101005 [cytosol] (Danio rerio)

BET3 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001257823.1, NP_001257825.1, NP_001257826.1, NP_055223.1, NP_001257824.1

OpenTargets

ENSG00000054116

GeneCards

O43617

HPA

ENSG00000054116-TRAPPC3

Ensembl

ENST00000373162, ENSP00000362261, ENSP00000480648, ENST00000373163, ENST00000617904, ENSP00000362256, ENSP00000362257, ENSG00000054116, ENST00000373166

PRO

O43617

Pharos - Targets

O43617

PDB

1SZ7, 2CFH, 2C0J, 3KXC

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.704	4
UniProt:Q9BZR8 BCL2L14	1	BCL2L14 [cytosol] (R-HSA-6791317)	0.527	2

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