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p-T68-CHEK2 dimerizes
Stable Identifier
R-HSA-5683774
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
p-T68-CHEK2 dimerizes (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
p-T68-CHEK2 dimerizes (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ATM-mediated phosphorylation of CHEK2 (CHK2, Cds1) on threonine residue T68 promotes formation of transitional CHEK2 homodimers primarily through intermolecular interactions of FHA domains and phospho-T68 residues of two CHEK2 protomers (Cai et al. 2009).
Literature References
PubMed ID
Title
Journal
Year
19782031
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
Cai, Z
,
Pavletich, NP
,
Chehab, NH
Mol. Cell
2009
Participants
Input
x 2
p-T68-CHEK2 [nucleoplasm]
(Homo sapiens)
Output
p-T68-CHEK2 dimer [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
Orthologous Events
p-T68-CHEK2 dimerizes (Bos taurus)
p-T68-CHEK2 dimerizes (Caenorhabditis elegans)
p-T68-CHEK2 dimerizes (Canis familiaris)
p-T68-CHEK2 dimerizes (Dictyostelium discoideum)
p-T68-CHEK2 dimerizes (Drosophila melanogaster)
p-T68-CHEK2 dimerizes (Gallus gallus)
p-T68-CHEK2 dimerizes (Mus musculus)
p-T68-CHEK2 dimerizes (Plasmodium falciparum)
p-T68-CHEK2 dimerizes (Rattus norvegicus)
p-T68-CHEK2 dimerizes (Saccharomyces cerevisiae)
p-T68-CHEK2 dimerizes (Schizosaccharomyces pombe)
p-T68-CHEK2 dimerizes (Sus scrofa)
p-T68-CHEK2 dimerizes (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2015-05-12)
Reviewed
Borowiec, JA (2015-06-12)
Created
Orlic-Milacic, M (2015-03-17)
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