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p-S,3T-CHEK2 [nucleoplasm]
Stable Identifier
R-HSA-5683784
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-T68,S379,T383,T387-CHEK2
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
CHEK2 phosphorylates TP53 (Homo sapiens)
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
Phosphorylation of MDM4 by CHEK2 (Homo sapiens)
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
p53-Independent G1/S DNA damage checkpoint (Homo sapiens)
p53-Independent DNA Damage Response (Homo sapiens)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Homo sapiens)
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Homo sapiens)
Phosphorylation of Cdc25C at Ser216 by CHEK2 (Homo sapiens)
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
p-T68-CHEK2 autophosphorylates (Homo sapiens)
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
CHEK2 phosphorylates BRCA1 (Homo sapiens)
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
p-T68-CHEK2 autophosphorylates (Homo sapiens)
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Methylation (Homo sapiens)
CHEK2 phosphorylates TTC5 (Homo sapiens)
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
CHEK2 phosphorylates TP53 (Homo sapiens)
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
Phosphorylation of MDM4 by CHEK2 (Homo sapiens)
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O96017 CHEK2
Gene Names
CHEK2, CDS1, CHK2, RAD53
Chain
chain:1-543
Reference Genes
BioGPS Gene:11200 CHEK2
COSMIC (genes):CHEK2 CHEK2
CTD Gene:11200 CHEK2
dbSNP Gene:11200 CHEK2
ENSEMBL:ENSG00000183765 CHEK2
ENSEMBL_homo_sapiens_GENE:ENSG00000183765.24 CHEK2
HGNC:16627 CHEK2
KEGG Gene (Homo sapiens):11200 CHEK2
Monarch:11200 CHEK2
NCBI Gene:11200 CHEK2
OMIM:604373 CHEK2
UCSC:O96017 CHEK2
Reference Transcript
RefSeq:NM_007194.3 CHEK2
RefSeq:NM_145862.2 CHEK2
RefSeq:NM_001005735.1 CHEK2
RefSeq:XM_011529845.2 CHEK2
RefSeq:XM_017028561.1 CHEK2
RefSeq:NM_001257387.1 CHEK2
Other Identifiers
11200
11753669_x_at
11755467_x_at
16933502
210416_PM_s_at
210416_s_at
3582924
3582926
3658279
3688788
3689056
37887_at
3935863
3935864
3935866
3956444
3956445
3956447
3956449
3956450
3956451
3956452
3956453
3956454
3956456
3956457
3956458
3956459
3956464
3956467
3956468
3956469
3956470
3956473
3956474
3956475
3956476
3956477
3956480
3956482
8075164
A_23_P109452
A_33_P3386760
GO:0000077
GO:0000086
GO:0000166
GO:0000278
GO:0000781
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005794
GO:0006281
GO:0006302
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0006974
GO:0006977
GO:0006978
GO:0007010
GO:0007049
GO:0007059
GO:0008630
GO:0010332
GO:0012501
GO:0016301
GO:0016310
GO:0016605
GO:0016740
GO:0019901
GO:0023052
GO:0030163
GO:0031573
GO:0031625
GO:0036211
GO:0042176
GO:0042770
GO:0042771
GO:0042802
GO:0042803
GO:0043226
GO:0044773
GO:0045893
GO:0046777
GO:0046872
GO:0050821
GO:0051301
GO:0070242
GO:0071480
GO:0090307
GO:0090399
GO:0106310
GO:0140014
GO:0140096
GO:1901796
HMNXSV003018841
HMNXSV003035313
HMNXSV003046320
ILMN_1759585
ILMN_2395236
ILMN_2395240
PH_hs_0008730
PH_hs_0032531
g13278893_3p_a_at
Participates
as an output of
p-T68-CHEK2 autophosphorylates (Homo sapiens)
Other forms of this molecule
p-T68-CHEK2 [nucleoplasm]
CHEK2 [nucleoplasm]
Inferred To
Homologues of p-S,3T-CHEK2 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-p-S,3T-CHEK2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S,3T-CHEK2 [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-S,3T-CHEK2 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-S,3T-CHEK2 [nucleoplasm]
(Gallus gallus)
phospho-p-S,3T-CHEK2 [nucleoplasm]
(Mus musculus)
phospho-p-S,3T-CHEK2 [nucleoplasm]
(Plasmodium falciparum)
phospho-p-S,3T-CHEK2 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S,3T-CHEK2 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-p-S,3T-CHEK2 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-CHEK2 [nucleoplasm]
(Bos taurus)
phospho-CHEK2 [nucleoplasm]
(Canis familiaris)
phospho-CHEK2 [nucleoplasm]
(Sus scrofa)
phospho-chek2 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 68
Coordinate
68
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 379
Coordinate
379
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 383
Coordinate
383
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 387
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_009125.1
,
XP_011528147.1
,
XP_016884050.1
,
NP_001244316.1
,
NP_001005735.1
,
NP_665861.1
ZINC - World Drugs
CHK2_HUMAN
Guide to Pharmacology - Targets
1988
OpenTargets
ENSG00000183765
ZINC - FDA approved
CHK2_HUMAN
ZINC - Substances
CHK2_HUMAN
ZINC target
O96017
ZINC - Biogenic
CHK2_HUMAN
PRO
O96017
PDB
2CN5
,
4A9T
,
4BDG
,
2YCR
,
2XM9
,
4BDH
,
2XM8
,
2WTC
,
2YCQ
,
2XK9
,
4BDA
,
2YIR
,
2YIQ
,
4BDF
,
2CN8
,
2WTJ
,
2W7X
,
2WTI
,
2YCS
,
4A9U
,
2WTD
,
4BDK
,
4BDD
,
2YIT
,
4BDB
,
2W0J
,
4BDE
,
3I6W
,
3VA4
,
4BDI
,
4A9S
,
2XBJ
,
4A9R
,
4BDJ
,
1GXC
,
2YCF
,
3I6U
,
4BDC
ZINC - Investigational
CHK2_HUMAN
IntEnz
2.7.11.1
GeneCards
O96017
HPA
ENSG00000183765-CHEK2
Ensembl
ENST00000404276
,
ENST00000650281
,
ENST00000405598
,
ENST00000417588
,
ENST00000403642
,
ENSP00000329012
,
ENST00000348295
,
ENSP00000372023
,
ENST00000448511
,
ENSP00000404400
,
ENSP00000390244
,
ENST00000382580
,
ENST00000425190
,
ENSP00000497000
,
ENSP00000404567
,
ENSP00000386087
,
ENSP00000385747
,
ENST00000649563
,
ENST00000433728
,
ENSG00000183765
,
ENSP00000384919
,
ENSP00000412901
,
ENSP00000496928
Pharos - Targets
O96017
Orphanet
15444
ZINC - Predictions - Purchasable
CHK2_HUMAN
HMDB Protein
HMDBP01248
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.733
7
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.72
7
UniProt:O96017 CHEK2
3
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
0.719
6
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.66
6
UniProt:Q15172 PPP2R5A
2
p-S28-PPP2R5A [cytosol]
(R-HSA-9836658)
PPP2R5A [cytosol]
(R-HSA-196235)
0.658
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.646
3
UniProt:P18887 XRCC1
1
XRCC1 [nucleoplasm]
(R-HSA-67455)
0.645
8
UniProt:Q13362-3 PPP2R5C
0.633
4
UniProt:P30304 CDC25A
6
PolyUb-CDC25A [cytosol]
(R-HSA-6782810)
CDC25A [nucleoplasm]
(R-HSA-143487)
CDC25A [cytosol]
(R-HSA-157410)
p-S124-CDC25A [nucleoplasm]
(R-HSA-143488)
p-S124-CDC25A [cytosol]
(R-HSA-69588)
p-S40,S116,S261-CDC25A [nucleoplasm]
(R-HSA-8863634)
0.623
2
UniProt:Q9NY61 AATF
1
AATF [cytosol]
(R-HSA-205071)
0.602
4
UniProt:Q13362-1 PPP2R5C
0.602
3
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.602
3
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.59
2
UniProt:O15355 PPM1G
0.564
2
UniProt:P27958-PRO_0000037577
0.556
3
UniProt:Q96KN1 LRAT2
0.543
3
UniProt:Q9UQ88-1 CDK11A
0.524
2
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.524
2
UniProt:Q5VTR2 RNF20
2
RNF20 [cytosol]
(R-HSA-9715141)
RNF20 [nucleoplasm]
(R-HSA-5689011)
0.508
3
UniProt:Q15173 PPP2R5B
2
p-S368-PPP2R5B [cytosol]
(R-HSA-6811453)
PPP2R5B [cytosol]
(R-HSA-535469)
0.508
2
UniProt:Q13362-2 PPP2R5C
0.508
2
UniProt:Q16537 PPP2R5E
1
PPP2R5E [cytosol]
(R-HSA-1638770)
0.508
3
UniProt:P0C6X7-PRO_0000037319 REP
0.508
2
UniProt:Q13007 IL24
1
IL24 [extracellular region]
(R-HSA-448438)
0.508
3
UniProt:Q9Y248 GINS2
1
GINS2 [nucleoplasm]
(R-HSA-176975)
0.499
2
UniProt:P56645 PER3
0.499
2
UniProt:P06725 UL83
1
CMVPP65 [viral tegument]
(R-HCY-5685583)
0.499
2
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