Reactome | p-S,3T-CHEK2 [nucleoplasm]

p-S,3T-CHEK2 [nucleoplasm]

Stable Identifier

R-HSA-5683784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-T68,S379,T383,T387-CHEK2

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O96017 CHEK2

Gene Names

CHEK2, CDS1, CHK2, RAD53

Chain

chain:1-543

Reference Genes

BioGPS Gene:11200 CHEK2

COSMIC (genes):CHEK2 CHEK2

CTD Gene:11200 CHEK2

dbSNP Gene:11200 CHEK2

ENSEMBL:ENSG00000183765 CHEK2

HGNC:16627 CHEK2

KEGG Gene (Homo sapiens):11200 CHEK2

Monarch:11200 CHEK2

NCBI Gene:11200 CHEK2

UCSC:O96017 CHEK2

Reference Transcript

Other Identifiers

0000730458

0002900711

11200

11721893_a_at

11753669_x_at

11755467_x_at

16933502

1878

1GXC

2030

210416_s_at

2CN5

2CN8

2W0J

2W7X

2WTC

2WTD

2WTI

2WTJ

2XBJ

2XK9

2XM8

2XM9

2YCF

2YCQ

2YCR

2YCS

2YIQ

2YIR

2YIT

3582924

3582926

3658279

3688788

3689056

37887_at

3935863

3935864

3935866

3956444

3956445

3956447

3956449

3956450

3956451

3956452

3956453

3956454

3956456

3956457

3956458

3956459

3956464

3956467

3956468

3956469

3956470

3956473

3956474

3956475

3956476

3956477

3956480

3I6U

3I6W

3VA4

4A9R

4A9S

4A9T

4A9U

4BDA

4BDB

4BDC

4BDD

4BDE

4BDF

4BDG

4BDH

4BDI

4BDJ

4BDK

8075164

A0A087X102

A0A3B3ITA7

A_23_P109452

A_33_P3386760

AAC83693

AAD11784

AAD48504

AAG17218

AAH04207

AAS58456

AAS58457

AAS58458

AAS58459

AAS58460

AAS58461

AAS58462

AAS58463

AAS58464

AAS58465

AAS58466

AAV41895

AB040105

AF086904

AF096279

AF174135

AF217975

AJ131197

AK290754

AL117330

AL121825

AY551295

AY551296

AY551297

AY551298

AY551299

AY551300

AY551301

AY551302

AY551303

AY551304

AY551305

AY800241

B7ZBF2

B7ZBF6

B7ZBF7

B7ZBF8

BAB17231

BAF83443

BC004207

C9JFD7

CAA10319

CAB002030

CAG30304

CCDS13843

CCDS13844

CCDS33629

CH471095

CHEK2

CHEK2-201

CHEK2-203

CHEK2-205

CHEK2-206

CHEK2-207

CHEK2-208

CHEK2-210

CHEK2-213

CHEK2-218

CHEK2-225

CHEK2-227

CR456418

EAW59755

ENSG00000183765

ENSP00000329012

ENSP00000372023

ENSP00000384835

ENSP00000384919

ENSP00000385747

ENSP00000386087

ENSP00000404400

ENSP00000404567

ENSP00000412901

ENSP00000496928

ENSP00000497000

ENST00000348295

ENST00000348295.7

ENST00000382580

ENST00000382580.6

ENST00000402731

ENST00000402731.5

ENST00000403642

ENST00000403642.5

ENST00000404276

ENST00000404276.6

ENST00000405598

ENST00000405598.5

ENST00000417588

ENST00000417588.5

ENST00000433728

ENST00000433728.5

ENST00000448511

ENST00000448511.5

ENST00000649563

ENST00000649563.1

ENST00000650281

ENST00000650281.1

EntrezGene:11200

EntrezGene:CHEK2

F8WCV2

g13278893_3p_a_at

GO:0000077

GO:0000086

GO:0000166

GO:0000278

GO:0000781

GO:0001302

GO:0001934

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005794

GO:0006259

GO:0006281

GO:0006302

GO:0006355

GO:0006464

GO:0006468

GO:0006915

GO:0006950

GO:0006974

GO:0006975

GO:0006977

GO:0006978

GO:0007010

GO:0007049

GO:0007165

GO:0007568

GO:0008150

GO:0008219

GO:0008630

GO:0009056

GO:0009058

GO:0010332

GO:0016301

GO:0016310

GO:0016605

GO:0016740

GO:0018105

GO:0019899

GO:0019901

GO:0022607

GO:0031625

GO:0034641

GO:0035690

GO:0042176

GO:0042770

GO:0042771

GO:0042802

GO:0042803

GO:0043167

GO:0043226

GO:0044257

GO:0044773

GO:0045893

GO:0046777

GO:0046872

GO:0050821

GO:0051301

GO:0071157

GO:0071480

GO:0072428

GO:0090307

GO:0090399

GO:0140014

GO:1901796

GO:1903416

GO:1903926

GO:2000002

GO:2000210

H7BZ30

H7C0V7

HGNC:16627

HPA001878

ILMN_1743378

ILMN_1759585

ILMN_2395236

ILMN_2395240

IPR000253

IPR000719

IPR001245

IPR008271

IPR008984

IPR011009

MIM:114480

MIM:176807

MIM:259500

MIM:604373

MIM:609265

NM_001005735

NM_001257387

NM_001349956

NM_007194

NM_145862

NP_001005735

NP_001244316

NP_001336885

NP_009125

NP_665861

PF00069

PF00498

PF07714

PH_hs_0008730

PH_hs_0032531

PR02045

SM00220

SM00240

UPI00000316FF

UPI000006EA3C

UPI0000072B3E

UPI000034E4A3

UPI000034E4A4

UPI000034E4A6

UPI000034E4A7

UPI000034E4A8

XM_006724114

XM_006724116

XM_011529839

XM_011529840

XM_011529841

XM_011529842

XM_011529845

XM_017028560

XM_017028561

XM_024452148

XM_024452149

XP_006724177

XP_006724179

XP_011528141

XP_011528142

XP_011528143

XP_011528144

XP_011528147

XP_016884049

XP_016884050

XP_024307916

XP_024307917

XR_937805

Participant Of

output

p-T68-CHEK2 autophosphorylates

Other forms of this molecule

p-T68-CHEK2 [nucleoplasm]

CHEK2 [nucleoplasm]

Inferred To

phospho-p-S,3T-CHEK2 [nucleoplasm] (Bos taurus)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Canis familiaris)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Danio rerio)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Drosophila melanogaster)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Gallus gallus)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Mus musculus)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Plasmodium falciparum)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Rattus norvegicus)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Sus scrofa)

phospho-p-S,3T-CHEK2 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 68

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 379

Coordinate

379

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 383

Coordinate

383

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 387

Coordinate

387

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_009125.1, NP_001005735.1, XP_011528147.1, NP_665861.1, NP_001244316.1, XP_016884050.1

ZINC - World Drugs

CHK2_HUMAN

OpenTargets

ENSG00000183765

ZINC - FDA approved

CHK2_HUMAN

ZINC - Substances

CHK2_HUMAN

ZINC - Biogenic

CHK2_HUMAN

ZINC target

O96017

PRO

O96017

PDB

3I6U, 4BDC, 4BDD, 2WTJ, 2YIR, 2CN8, 4BDA, 2XBJ, 4BDJ, 4BDI, 4BDB, 2W7X, 2YIT, 4BDK, 2YCF, 2CN5, 2XM8, 2W0J, 2WTD, 4BDG, 4BDH, 2XK9, 2YIQ, 2YCQ, 2WTC, 4A9R, 3I6W, 4BDE, 2WTI, 2YCS, 4A9S, 3VA4, 1GXC, 4A9T, 4BDF, 2XM9, 4A9U, 2YCR

ZINC - Investigational

CHK2_HUMAN

IntEnz

2.7.11.1

GeneCards

O96017

ZINC - Predictions - Purchasable

CHK2_HUMAN

Orphanet

15444

HMDB Protein

HMDBP01248

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.733	7
UniProt:P53350 PLK1	4	p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [cytosol] (R-HSA-164603)	0.72	7
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824)	0.719	6
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.66	6
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.646	3
UniProt:P18887 XRCC1	1	XRCC1 [nucleoplasm] (R-HSA-67455)	0.645	8
UniProt:Q13362-3 PPP2R5C			0.633	4
UniProt:P30304 CDC25A	6	p-S123-CDC25A [nucleoplasm] (R-HSA-143488) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S123-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634) PolyUb-CDC25A [cytosol] (R-HSA-6782810)	0.623	2
UniProt:Q13362-1 PPP2R5C			0.602	3
UniProt:P06400 RB1	3	p-S795-RB1 [nucleoplasm] (R-HSA-69226) RB1 [nucleoplasm] (R-HSA-68642) p-RB1 [nucleoplasm] (R-HSA-188389)	0.602	3
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.602	4
UniProt:P27958-PRO_0000037577			0.556	3
UniProt:Q96KN1 LRAT2			0.543	3
UniProt:Q9UQ88-1 CDK11A			0.524	2
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425)	0.524	2
UniProt:Q15173 PPP2R5B	2	PPP2R5B [cytosol] (R-HSA-535469) p-S368-PPP2R5B [cytosol] (R-HSA-6811453)	0.508	2
UniProt:Q15172 PPP2R5A	1	PPP2R5A [cytosol] (R-HSA-196235)	0.508	2
UniProt:Q5VTR2 RNF20	1	RNF20 [nucleoplasm] (R-HSA-5689011)	0.508	3
UniProt:Q13362-2 PPP2R5C			0.508	2
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.508	3
UniProt:Q13007 IL24	1	IL24 [extracellular region] (R-HSA-448438)	0.508	3
UniProt:P56645 PER3			0.499	2
UniProt:P06725 UL83	1	CMVPP65 [viral tegument] (R-HCY-5685583)	0.499	2
UniProt:Q9Y248 GINS2	1	GINS2 [nucleoplasm] (R-HSA-176975)	0.499	2