SFTPA genes produce SFTPA proteins

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R-HSA-5683879
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Reaction [omitted]
Species
Homo sapiens
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Human SFTPA1, 2 and 3 produces the equivalent pulmonary surfactant-associated proteins A1, A2 and A3. Their function is to bind surfactant phospholipids and contribute to lowering the surface tension at the air-liquid interface in the alveoli (White et al. 1985, Flores et al. 1986, Schicht et al. 2014). Surfactant proteins A and D function as innate immunity molecules and inflammatory mediators in the lung (Silveyra & Floros 2013). Transcription factor GATA-6 (GATA6) can bind to a cis-acting element in the surfactant protein A (SFTPA) gene promoter, activating the transcriptional activity of the gene (Bruno et al. 2000). The final processed products for SFTPA1 and 2 are six sets of trimers (Haagsman et al. 1989).

Literature References
PubMed ID Title Journal Year
2995821 Isolation and characterization of the human pulmonary surfactant apoprotein gene

White, RT, Damm, D, Miller, J, Spratt, K, Schilling, J, Hawgood, S, Benson, B, Cordell, B

Nature 1985
10625644 GATA-6 activates transcription of surfactant protein A

Bruno, MD, Korfhagen, TR, Liu, C, Morrisey, EE, Whitsett, JA

J. Biol. Chem. 2000
3755136 Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein

Floros, J, Steinbrink, R, Jacobs, K, Phelps, D, Kriz, R, Recny, M, Sultzman, L, Jones, S, Taeusch, HW, Frank, HA

J. Biol. Chem. 1986
2610270 Studies of the structure of lung surfactant protein SP-A

Haagsman, HP, White, RT, Schilling, J, Lau, K, Benson, BJ, Golden, J, Hawgood, S, Clements, JA

Am. J. Physiol. 1989
24743970 SFTA3, a novel protein of the lung: three-dimensional structure, characterisation and immune activation

Schicht, M, Rausch, F, Finotto, S, Mathews, M, Mattil, A, Schubert, M, Koch, B, Traxdorf, M, Bohr, C, Worlitzsch, D, Brandt, W, Garreis, F, Sel, S, Paulsen, F, Bräuer, L

Eur. Respir. J. 2014
23069847 Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2

Silveyra, P, Floros, J

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