LMCD1 binds GATA6, sequestering it

Stable Identifier
R-HSA-5683888
Type
Reaction [binding]
Species
Homo sapiens
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The GATA transcription factors regulate gene expression in a variety of cell types including cardiovascular, pulmonary and hematopoietic tissues. LIM and cysteine-rich domains protein 1 (LMCD1) is a transcriptional cofactor that binds GATA6 and thus restricts its function by inhibiting its DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes (Rath et al. 2005).

Literature References
PubMed ID Title Journal Year
16199866 LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding

Rath, N, Wang, Z, Lu, MM, Morrisey, EE

Mol. Cell. Biol. 2005
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