Reactome | p-Y143-H2AFX [nucleoplasm]

p-Y143-H2AFX [nucleoplasm]

Stable Identifier

R-HSA-5683942

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-Y142-H2AFX

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P16104 H2AX

Gene Names

H2AFX, H2AX

Chain

initiator methionine:1, chain:2-143

Reference Genes

BioGPS Gene:3014 H2AFX

COSMIC (genes):H2AFX H2AFX

CTD Gene:3014 H2AFX

dbSNP Gene:3014 H2AFX

ENSEMBL:ENSG00000188486 H2AFX

HGNC:4739 H2AFX

KEGG Gene (Homo sapiens):3014 H2AFX

Monarch:3014 H2AFX

NCBI Gene:3014 H2AFX

OMIM:601772 H2AFX

UCSC:P16104 H2AFX

Reference Transcript

RefSeq:NM_002105.2 H2AFX

Other Identifiers

0000060736

11754243_a_at

16745236

205436_PM_s_at

205436_s_at

212525_3p_s_at

212525_PM_s_at

212525_s_at

3014

3394184

3394185

3394186

3394187

3394188

3394189

3394190

40195_at

7952179

A_24_P38895

GE59719

GO:0000003

GO:0000077

GO:0000228

GO:0000724

GO:0000781

GO:0000785

GO:0000786

GO:0000794

GO:0001673

GO:0001741

GO:0003674

GO:0003677

GO:0003684

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005813

GO:0005815

GO:0005856

GO:0006259

GO:0006281

GO:0006302

GO:0006310

GO:0006334

GO:0006950

GO:0006974

GO:0007049

GO:0007165

GO:0007283

GO:0007568

GO:0008150

GO:0010212

GO:0016607

GO:0019899

GO:0021987

GO:0022607

GO:0032991

GO:0034641

GO:0035861

GO:0042393

GO:0043226

GO:0045739

GO:0046982

GO:0048856

GO:0051276

GO:0051321

GO:0065003

GO:0070062

GO:0071480

GO:0090398

GO:0090734

HMNXSV003055476

Hs.147097.1.A1_3p_a_at

ILMN_1785756

ILMN_2200331

PH_hs_0008797

PH_hs_0040597

TC11002362.hg

X14850_at

g4504252_3p_a_at

Participates

as a component of

p-Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]

p-S140-H2AFX [nucleoplasm]

p-S140,Y143-H2AFX [nucleoplasm]

H2AFX [nucleoplasm]

Me2sR4-H2AFX [nucleoplasm]

H2AFX [extracellular region]

Inferred To

phospho-zgc:56685 [nucleoplasm] (Danio rerio)

phospho-hta1 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of p-Y143-H2AFX [nucleoplasm] (Danio rerio)

Homologues of p-Y143-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of p-Y143-H2AFX [nucleoplasm] (Xenopus tropicalis)

phospho-h2ax1 [nucleoplasm] (Danio rerio)

phospho-h2az2 [nucleoplasm] (Xenopus tropicalis)

phospho-H2AX [nucleoplasm] (Canis familiaris)

phospho-H2AX [nucleoplasm] (Sus scrofa)

phospho-H2afx [nucleoplasm] (Rattus norvegicus)

Ghost homologue of p-Y143-H2AFX [nucleoplasm] (Bos taurus)

phospho-H2ax [nucleoplasm] (Mus musculus)

phospho-XB5815362 [provisional:cyp2j6] [nucleoplasm] (Xenopus tropicalis)

phospho-si:ch73-340n8.4 [nucleoplasm] (Danio rerio)

phospho-hta2 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-p-Y143-H2AFX [nucleoplasm] (Gallus gallus)

phospho-p-Y143-H2AFX [nucleoplasm] (Plasmodium falciparum)

Modified Residues

Name

O4'-phospho-L-tyrosine at 143

Coordinate

143

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002096.1

GeneCards

P16104

HPA

ENSG00000188486-H2AX

Ensembl

ENSP00000364310, ENST00000530167, ENSP00000434024, ENST00000375167, ENSG00000188486

PRO

P16104

Pharos - Targets

P16104

PDB

6K1J, 2DYP, 3U3Z, 6K1I, 6K1K, 2AZM, 2D31, 3SZM, 3SHV, 6ZWK, 1YDP, 3SQD

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14676 MDC1	6	monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061)	0.965	21
UniProt:O60934 NBN	3	NBN [cytosol] (R-HSA-5684005) NBN [nucleoplasm] (R-HSA-75163) p-S343-NBN [nucleoplasm] (R-HSA-75237)	0.859	14
UniProt:P49959 MRE11	2	MRE11A [nucleoplasm] (R-HSA-59544) MRE11A [cytosol] (R-HSA-3204309)	0.809	7
UniProt:P62805 H4C1	17	HIST1H4A [extracellular region] (R-HSA-977569) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.802	5
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.798	10
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.793	6
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.714	4
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.667	6
UniProt:Q16695 H3-4	3	HIST3H3 [nucleoplasm] (R-HSA-181914) Me3K5-HIST3H3 [nucleoplasm] (R-HSA-2245188) Me2K5-HIST3H3 [nucleoplasm] (R-HSA-2245186)	0.641	12
UniProt:P02545 LMNA	3	LMNA(1-664) [nucleoplasm] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.604	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.577	6
UniProt:O15297 PPM1D	1	PPM1D [nucleoplasm] (R-HSA-2562518)	0.544	3
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.537	9
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.527	2
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	2
UniProt:Q92878 RAD50	1	RAD50 [nucleoplasm] (R-HSA-75160)	0.527	3
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.524	3
UniProt:Q13315 ATM	5	ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [peroxisomal matrix] (R-HSA-9665169) ATM [cytosol] (R-HSA-9665171)	0.491	2

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