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p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
Stable Identifier
R-HSA-5683972
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nucleosome with diphosphorylated histone H2AFX
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
ATM phosphorylates EYA1-4 (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Participants
components
2 x
HIST1H4 [nucleoplasm] (Homo sapiens)
2 x
HIST3H3 [nucleoplasm] (Homo sapiens)
2 x
Histone H2B [nucleoplasm] (Homo sapiens)
2 x
p-S140,Y143-H2AFX [nucleoplasm] (Homo sapiens)
Participant Of
hasComponent
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
Inferred To
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Danio rerio)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Rattus norvegicus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Sus scrofa)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
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