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p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
Stable Identifier
R-HSA-5683972
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nucleosome with diphosphorylated histone H2AFX
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
ATM phosphorylates EYA1-4 (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Participants
components
x 2
HIST1H4 [nucleoplasm]
(Homo sapiens)
x 2
HIST3H3 [nucleoplasm]
(Homo sapiens)
x 2
Histone H2B [nucleoplasm]
(Homo sapiens)
x 2
p-S140,Y143-H2AFX [nucleoplasm]
(Homo sapiens)
Participates
as a component of
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Inferred To
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Bos taurus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Caenorhabditis elegans)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Canis familiaris)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Danio rerio)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Dictyostelium discoideum)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Gallus gallus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Mus musculus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Rattus norvegicus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Schizosaccharomyces pombe)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Sus scrofa)
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