APBB1 and MAPK8 bind diphosphorylated H2AFX

Stable Identifier
R-HSA-5683986
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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APBB1 and MAPK8 bind diphosphorylated H2AFX
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In the absence of sufficient EYA1-4 activity, APBB1 (FE65) binds diphosphorylated H2AFX and recruits MAPK8 (JNK1) to H2AFX. This triggers pro-apoptotic signaling and targets the affected cell for apoptosis instead of DNA repair (Cook et al. 2009).
Literature References
PubMed ID Title Journal Year
19234442 Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

Telese, F, Wang, X, Cook, PJ, Rosenfeld, MG, Glass, CK, Ju, BG

Nature 2009
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Orthologous Events
APBB1 and MAPK8 bind diphosphorylated H2AFX (Bos taurus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Gallus gallus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-17)
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