Reactome | NBN [cytosol]

NBN [cytosol]

Stable Identifier

R-HSA-5684005

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NBS1

Locations in the PathwayBrowser for interactor UniProt:Q9BXW9 FANCD2

Expand all

External Reference Information

External Reference

UniProt:O60934 NBN

Gene Names

NBN, NBS, NBS1, P95

Chain

chain:1-754

Reference Genes

BioGPS Gene:4683 NBN

COSMIC (genes):NBN NBN

CTD Gene:4683 NBN

dbSNP Gene:4683 NBN

ENSEMBL:ENSG00000104320 NBN

HGNC:7652 NBN

KEGG:hsa:4683 NBN

Monarch:4683 NBN

NCBI Gene:4683 NBN

OMIM:602667 NBN

UCSC:O60934 NBN

Reference Transcript

Other Identifiers

11720395_a_at

11720396_x_at

11720397_a_at

11720398_a_at

11755809_a_at

17078916

202905_PM_x_at

202905_x_at

202906_PM_s_at

202906_s_at

202907_PM_s_at

202907_s_at

217299_PM_s_at

217299_s_at

3143962

3143963

3143965

3143967

3143969

3143971

3143972

3143973

3143974

3143975

3143976

3143977

3143978

3143979

3143980

3143981

3143983

3143984

3143985

3143986

3143987

3143988

3143989

3143991

3143992

3143993

3143994

3143995

3143996

3143998

3143999

3144000

3144001

3144003

3144004

3144005

3144006

3144007

3144008

3144009

3144010

3144011

3144012

3144013

3144014

3144015

35153_at

4683

8151711

A_23_P251480

A_24_P278126

GE54544

GE85327

GO:0000077

GO:0000723

GO:0000724

GO:0000729

GO:0000781

GO:0001701

GO:0001832

GO:0002376

GO:0003677

GO:0003684

GO:0005515

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005730

GO:0005794

GO:0005829

GO:0006281

GO:0006302

GO:0006310

GO:0006325

GO:0006974

GO:0007093

GO:0007095

GO:0007405

GO:0016605

GO:0022414

GO:0030174

GO:0030330

GO:0030870

GO:0031848

GO:0031860

GO:0031954

GO:0032200

GO:0032206

GO:0032508

GO:0033674

GO:0035825

GO:0035861

GO:0042393

GO:0042405

GO:0043226

GO:0043247

GO:0043539

GO:0044818

GO:0045190

GO:0048856

GO:0050877

GO:0050885

GO:0051321

GO:0051726

GO:0060090

GO:0062176

GO:0070533

GO:0070534

GO:0090656

GO:0090737

GO:0097193

GO:0097681

GO:0098687

GO:0098772

GO:0110025

GO:0140031

GO:0140297

GO:0140463

GO:1904354

GO:1905168

GO:1990166

HMNXSV003050757

Hs.25812.0.S1_3p_a_at

Hs.25812.0.S2_3p_a_at

ILMN_1717016

ILMN_1734833

ILMN_2358041

PH_hs_0002272

TC08001400.hg

g6996019_3p_a_at

Participates

as a component of

NBN:KPNA2 [cytosol] (Homo sapiens)

as an input of

NBN binds KPNA2 (Homo sapiens)

Other forms of this molecule

p-S343-NBN [nucleoplasm]

NBN [nucleoplasm]

Inferred To

NBN [cytosol] (Bos taurus)

NBN [cytosol] (Canis familiaris)

NBN [cytosol] (Gallus gallus)

NBN [cytosol] (Sus scrofa)

nbn [cytosol] (Danio rerio)

Nbn [cytosol] (Mus musculus)

Nbn [cytosol] (Rattus norvegicus)

nbs [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

XP_011515347.1, NP_001019859.1, NP_002476.2

OpenTargets

ENSG00000104320

ENSEMBL

ENSP00000513245, ENSP00000265433, ENST00000697292, ENST00000265433, ENSP00000513229, ENST00000697310

HPA

ENSG00000104320-NBN

PRO

O60934

Pharos - Targets

O60934

Orphanet

NBN

GlyGen

O60934

PDB

8BAH, 5WQD, 7SID

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14676 MDC1	6	MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546)	0.968	33
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.859	14
UniProt:P49959 MRE11	2	MRE11A [nucleoplasm] (R-HSA-59544) MRE11A [cytosol] (R-HSA-3204309)	0.822	5
UniProt:Q92878 RAD50	1	RAD50 [nucleoplasm] (R-HSA-75160)	0.712	4
UniProt:Q13428 TCOF			0.678	10
UniProt:Q99986 VRK1	2	VRK1 [cytosol] (R-HSA-2995381) VRK1 [nucleoplasm] (R-HSA-2528998)	0.65	13
UniProt:O75943 RAD17	1	RAD17 [nucleoplasm] (R-HSA-3008665)	0.632	5
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.632	5
UniProt:Q9BXW9 FANCD2	3	FANCD2 [nucleoplasm] (R-HSA-419522) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318)	0.626	6
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.602	5
UniProt:Q99708 RBBP8	4	p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399) Ac-K-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138)	0.564	2
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.528	2
UniProt:P08218 CEL2B			0.527	2
UniProt:Q9BRK4 LZTS2			0.527	2
UniProt:P13497 BMP1	1	BMP1 [extracellular region] (R-HSA-2002393)	0.527	2
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.499	2

Cite Us!