KPNA2 translocates NBN to the nucleus

Stable Identifier
R-HSA-5684006
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
KPNA2 translocates NBN to the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

KPNA2 facilitates the translocation of NBN (NBS1) to the nucleus, thereby making NBN available for the formation of MRN complexes in response to DNA double strand breaks (DSBs) (Tseng et al. 2005).

Literature References
PubMed ID Title Journal Year
16188882 Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1

Tseng, SF, Chang, CY, Wu, KJ, Teng, SC

J. Biol. Chem. 2005
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
KPNA2 translocates NBN to the nucleus (Bos taurus)
KPNA2 translocates NBN to the nucleus (Canis familiaris)
KPNA2 translocates NBN to the nucleus (Danio rerio)
KPNA2 translocates NBN to the nucleus (Drosophila melanogaster)
KPNA2 translocates NBN to the nucleus (Mus musculus)
KPNA2 translocates NBN to the nucleus (Rattus norvegicus)
KPNA2 translocates NBN to the nucleus (Schizosaccharomyces pombe)
KPNA2 translocates NBN to the nucleus (Sus scrofa)
KPNA2 translocates NBN to the nucleus (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-17)
Cite Us!