Reactome | PIAS4 SUMOylates MDC1

PIAS4 SUMOylates MDC1

Stable Identifier

R-HSA-5684052

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS4 SUMOylates MDC1 at lysine residue K1840. The exact timing and regulation of this modification is not known (Luo et al. 2012, Yin et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22661230	SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage Seifert, A, Golebiowski, F, Maure, JF, Hay, RT, Chua, JS, Yin, Y	Genes Dev.	2012
22635276	Sumoylation of MDC1 is important for proper DNA damage response Lou, Z, Yuan, J, Luo, K, Wang, L, Zhang, H	EMBO J.	2012

Participants

Input

Output

Participates

as an event of

Processing of DNA double-strand break ends (Homo sapiens)

Catalyst Activity

SUMO transferase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm]

Physical Entity

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Homo sapiens)

Activity

SUMO transferase activity (GO:0019789)

Orthologous Events

PIAS4 SUMOylates MDC1 (Bos taurus)

PIAS4 SUMOylates MDC1 (Gallus gallus)

PIAS4 SUMOylates MDC1 (Mus musculus)

PIAS4 SUMOylates MDC1 (Rattus norvegicus)

PIAS4 SUMOylates MDC1 (Sus scrofa)

Authored

Orlic-Milacic, M (2015-05-12)