Reactome | K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]

K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]

Stable Identifier

R-HSA-5684074

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        RNF4 ubiquitinates MDC1 (Homo sapiens)
        
        K48PolyUb:SUMO2:K1840,p-5T-MDC1 dimer [nucleoplasm] (Homo sapiens)
        
        K48PolyUb:SUMO2:K1840,p-5T-MDC1 [nucleoplasm] (Homo sapiens)
        
        K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14676 MDC1

Gene Names

MDC1, KIAA0170, NFBD1

Chain

chain:1-2089

Reference Genes

BioGPS Gene:9656 MDC1

COSMIC (genes):MDC1 MDC1

CTD Gene:9656 MDC1

dbSNP Gene:9656 MDC1

ENSEMBL:ENSG00000137337 MDC1

ENSEMBL:ENSG00000206481 MDC1

ENSEMBL:ENSG00000224587 MDC1

ENSEMBL:ENSG00000225589 MDC1

ENSEMBL:ENSG00000228575 MDC1

ENSEMBL:ENSG00000231135 MDC1

ENSEMBL:ENSG00000234012 MDC1

ENSEMBL:ENSG00000237095 MDC1

HGNC:21163 MDC1

KEGG Gene (Homo sapiens):9656 MDC1

Monarch:9656 MDC1

NCBI Gene:9656 MDC1

OMIM:607593 MDC1

UCSC:Q14676 MDC1

Reference Transcript

Other Identifiers

0006200402

11748150_a_at

11748405_a_at

11751800_a_at

11758138_s_at

17016966

17026706

17028857

17031635

17034090

17036357

17039133

17041700

203061_s_at

203062_s_at

2948565

2948566

2948567

2948568

2948569

2948570

2948571

2948572

2948574

2948575

2948577

2948578

2948579

2948580

2948581

2948582

2948583

2948584

2948586

2ADO

2AZM

2ETX

32661_s_at

32662_at

3K05

3UEO

3UMZ

3UN0

3UNM

3UNN

3UOT

6915

8124813

8178404

9656

A0A087X0R2

A0A1U9XBC1

A0A1U9XBE3

A0A1U9XBF2

A2AB05

A2AB06

A2AB07

A_23_P19455

AAI10646

AAI52557

AB088099

AB103605

AB202097

AL662797

AL662848

AL845353

AQY78598

AQY78600

AQY78604

AQY78607

AQY78609

BA000025

BAA11487

BAB63322

BAC54931

BAE78617

BAF31266

BC110645

BC152556

BX248307

BX927283

CAH18685

CCDS34384

CH471081

CR749828

CR759873

CR788240

CR936878

D79992

D79992_at

EAX03321

ENSG00000137337

ENSG00000206481

ENSG00000224587

ENSG00000225589

ENSG00000228575

ENSG00000231135

ENSG00000234012

ENSG00000237095

ENSP00000365588

ENSP00000373060

ENSP00000387429

ENSP00000396484

ENSP00000404318

ENSP00000409167

ENSP00000415212

ENSP00000416511

ENST00000376406

ENST00000376406.7

ENST00000383566

ENST00000420019

ENST00000420320

ENST00000427406

ENST00000435664

ENST00000440369

ENST00000449153

EntrezGene:9656

EntrezGene:MDC1

g7661965_3p_a_at

GE87930

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005925

GO:0006259

GO:0006281

GO:0006303

GO:0006950

GO:0006974

GO:0007049

GO:0008022

GO:0008150

GO:0016604

GO:0031573

GO:0034641

GO:0042802

GO:0043226

GO:0070975

HGNC:21163

HPA006915

Hs.277585.0.A1_3p_a_at

ILMN_1814122

IPR000253

IPR001357

IPR008984

IPR036420

KY500445

KY500447

KY500451

KY500454

KY500456

MDC1

MDC1-201

MDC1-210

MDC1-219

MDC1-228

MDC1-240

MDC1-248

MDC1-255

MDC1-266

MIM:607593

NM_014641

NP_055456

PF00498

PF16770

PH_hs_0020142

SM00240

TC06001507.hg

TC6_apd_hap1000077.hg

TC6_cox_hap2000141.hg

TC6_dbb_hap3000130.hg

TC6_mann_hap4000119.hg

TC6_mcf_hap5000120.hg

TC6_qbl_hap6000131.hg

TC6_ssto_hap7000121.hg

UPI00001AF453

UPI00004A3B34

UPI0000EE070F

XM_005249492

XM_005249493

XM_005249494

XM_005249497

XM_005249498

XM_011515001

XM_011515003

XM_011515004

XM_017011519

XM_017011520

XM_017011521

XM_017011522

XP_005249549

XP_005249550

XP_005249551

XP_005249554

XP_005249555

XP_011513303

XP_011513305

XP_011513306

XP_016867008

XP_016867009

XP_016867010

XP_016867011

Participant Of

hasComponent

K48PolyUb:SUMO2:K1840,p-5T-MDC1 [nucleoplasm]

Other forms of this molecule

SUMO1-K1840-MDC1 [nucleoplasm]

SUMO2,3-K1840-MDC1 [nucleoplasm]

SUMO2-K1840,p-5T-MDC1 [nucleoplasm]

MDC1 [nucleoplasm]

p-5T-MDC1 [nucleoplasm]

Inferred To

phospho-K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (Canis familiaris)

phospho-K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (Mus musculus)

phospho-K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-threonine at 4

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 699

Coordinate

699

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 719

Coordinate

719

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 752

Coordinate

752

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 765

Coordinate

765

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

Inter-chain Crosslink via sumoylated lysine at 1840 and 93

Coordinate

1840

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

ubiquitinylated lysine (K48polyUb [nucleoplasm]) at unknown position

Modification

K48polyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_011513305.1, XP_005249551.1, XP_016867008.1, XP_011513303.1, NP_055456.2

OpenTargets

ENSG00000137337

GeneCards

Q14676

PRO

Q14676

PDB

3UMZ, 3K05, 3UNM, 3UN0, 2AZM, 3UNN, 2ADO, 3UOT, 3UEO, 2ETX

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60934 NBN	3	NBN [nucleoplasm] (R-HSA-75163) NBN [cytosol] (R-HSA-5684005) p-S343-NBN [nucleoplasm] (R-HSA-75237)	0.968	33
UniProt:P16104 H2AFX	7	p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [extracellular region] (R-HSA-977583)	0.965	21
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.725	11
UniProt:Q92878 RAD50	1	RAD50 [nucleoplasm] (R-HSA-75160)	0.69	9
UniProt:P49959 MRE11	2	MRE11A [nucleoplasm] (R-HSA-59544) MRE11A [cytosol] (R-HSA-3204309)	0.69	9
UniProt:P38398 BRCA1	5	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) BRCA1 [nucleoplasm] (R-HSA-50949) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.648	4
UniProt:Q13315 ATM	3	Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484)	0.623	3
UniProt:O96028-1 NSD2			0.602	3
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.591	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.577	4
UniProt:Q14676 MDC1	6	SUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) SUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236)	0.564	2
UniProt:Q9BXW9 FANCD2	3	p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318)	0.527	2
UniProt:O76064-1 RNF8			0.524	2
UniProt:Q06609 RAD51	2	p-T309-RAD51 [nucleoplasm] (R-HSA-5685231) RAD51 [nucleoplasm] (R-HSA-62637)	0.524	3