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K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
Stable Identifier
R-HSA-5684074
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
RNF4 ubiquitinates MDC1 (Homo sapiens)
K48PolyUb:SUMO2:K1840,p-5T-MDC1 dimer [nucleoplasm] (Homo sapiens)
K48PolyUb:SUMO2:K1840,p-5T-MDC1 [nucleoplasm] (Homo sapiens)
K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14676 MDC1
Gene Names
MDC1, KIAA0170, NFBD1
Chain
chain:1-2089
Reference Genes
BioGPS Gene:9656 MDC1
COSMIC (genes):MDC1 MDC1
CTD Gene:9656 MDC1
dbSNP Gene:9656 MDC1
ENSEMBL:ENSG00000137337 MDC1
ENSEMBL:ENSG00000206481 MDC1
ENSEMBL:ENSG00000224587 MDC1
ENSEMBL:ENSG00000225589 MDC1
ENSEMBL:ENSG00000228575 MDC1
ENSEMBL:ENSG00000231135 MDC1
ENSEMBL:ENSG00000234012 MDC1
ENSEMBL:ENSG00000237095 MDC1
HGNC:21163 MDC1
KEGG Gene (Homo sapiens):9656 MDC1
Monarch:9656 MDC1
NCBI Gene:9656 MDC1
OMIM:607593 MDC1
UCSC:Q14676 MDC1
Reference Transcript
RefSeq:XM_011515003.2 MDC1
RefSeq:NM_014641.2 MDC1
RefSeq:XM_017011519.1 MDC1
RefSeq:XM_005249494.4 MDC1
RefSeq:XM_011515001.2 MDC1
Other Identifiers
0006200402
11748150_a_at
11748405_a_at
11751800_a_at
11758138_s_at
17016966
17026706
17028857
17031635
17034090
17036357
17039133
17041700
203061_s_at
203062_s_at
2948565
2948566
2948567
2948568
2948569
2948570
2948571
2948572
2948574
2948575
2948577
2948578
2948579
2948580
2948581
2948582
2948583
2948584
2948586
32661_s_at
32662_at
8124813
8178404
9656
A_23_P19455
D79992_at
GE87930
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005925
GO:0006259
GO:0006281
GO:0006303
GO:0006950
GO:0006974
GO:0007049
GO:0008022
GO:0008150
GO:0016604
GO:0031573
GO:0034641
GO:0042802
GO:0043226
GO:0070975
Hs.277585.0.A1_3p_a_at
ILMN_1814122
PH_hs_0020142
TC06001507.hg
TC6_apd_hap1000077.hg
TC6_cox_hap2000141.hg
TC6_dbb_hap3000130.hg
TC6_mann_hap4000119.hg
TC6_mcf_hap5000120.hg
TC6_qbl_hap6000131.hg
TC6_ssto_hap7000121.hg
g7661965_3p_a_at
Participant Of
hasComponent
K48PolyUb:SUMO2:K1840,p-5T-MDC1 [nucleoplasm]
Other forms of this molecule
SUMO1-K1840-MDC1 [nucleoplasm]
SUMO2,3-K1840-MDC1 [nucleoplasm]
SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
MDC1 [nucleoplasm]
p-5T-MDC1 [nucleoplasm]
Inferred To
phospho-MDC1 [nucleoplasm] (Canis familiaris)
phospho-mdc1 [nucleoplasm] (Danio rerio)
phospho-Mdc1 [nucleoplasm] (Mus musculus)
phospho-Mdc1 [nucleoplasm] (Rattus norvegicus)
Modified Residues
Name
O-phospho-L-threonine at 4
Coordinate
4
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 699
Coordinate
699
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 719
Coordinate
719
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 752
Coordinate
752
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 765
Coordinate
765
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
Inter-chain Crosslink via sumoylated lysine at 1840 and 93
Coordinate
1840
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
ubiquitinylated lysine (K48polyUb [nucleoplasm]) at unknown position
Modification
K48polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_055456.2
,
XP_011513303.1
,
XP_011513305.1
,
XP_005249551.1
,
XP_016867008.1
OpenTargets
ENSG00000137337
HPA
ENSG00000137337-MDC1
GeneCards
Q14676
Ensembl
ENSG00000231135
,
ENSP00000415212
,
ENST00000376406
,
ENST00000420320
,
ENSP00000416511
,
ENST00000435664
,
ENSG00000228575
,
ENSP00000409167
,
ENSG00000234012
,
ENST00000449153
,
ENST00000420019
,
ENSP00000365588
,
ENSP00000404318
,
ENSG00000225589
,
ENSG00000224587
,
ENST00000383566
,
ENST00000440369
,
ENSG00000206481
,
ENST00000427406
,
ENSP00000373060
,
ENSG00000137337
,
ENSG00000237095
,
ENSP00000396484
,
ENSP00000387429
PRO
Q14676
PDB
2AZM
,
2ADO
,
3UN0
,
3UOT
,
2ETX
,
3UEO
,
3UNN
,
3K05
,
3UMZ
,
3UNM
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60934 NBN
3
NBN [nucleoplasm]
(R-HSA-75163)
NBN [cytosol]
(R-HSA-5684005)
p-S343-NBN [nucleoplasm]
(R-HSA-75237)
0.968
33
UniProt:P16104 H2AX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [extracellular region]
(R-HSA-977583)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
H2AFX [nucleoplasm]
(R-HSA-56151)
0.965
21
UniProt:O76064 RNF8
1
RNF8 [nucleoplasm]
(R-HSA-5682539)
0.725
11
UniProt:Q92878 RAD50
1
RAD50 [nucleoplasm]
(R-HSA-75160)
0.69
9
UniProt:P49959 MRE11
2
MRE11A [nucleoplasm]
(R-HSA-59544)
MRE11A [cytosol]
(R-HSA-3204309)
0.69
9
UniProt:P38398 BRCA1
27
SUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
SUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
BRCA1 C64R [nucleoplasm]
(R-HSA-9700907)
BRCA1 C61G [nucleoplasm]
(R-HSA-9700890)
BRCA1 C39Y [nucleoplasm]
(R-HSA-9700938)
BRCA1 H41R [nucleoplasm]
(R-HSA-9700921)
BRCA1 C24R [nucleoplasm]
(R-HSA-9663198)
BRCA1 H41A [nucleoplasm]
(R-HSA-9700927)
BRCA1 M18T [nucleoplasm]
(R-HSA-9700911)
BRCA1 C47G [nucleoplasm]
(R-HSA-9700941)
BRCA1 C64G [nucleoplasm]
(R-HSA-9700899)
BRCA1 C44F [nucleoplasm]
(R-HSA-9700944)
BRCA1 T37R [nucleoplasm]
(R-HSA-9700934)
BRCA1 C27A [nucleoplasm]
(R-HSA-9700916)
BRCA1 H41Q [nucleoplasm]
(R-HSA-9700923)
BRCA1 Q12Tfs*5 [nucleoplasm]
(R-HSA-9700953)
BRCA1 E23Afs*18 [nucleoplasm]
(R-HSA-9700959)
BRCA1 C61Y [nucleoplasm]
(R-HSA-9700894)
BRCA1 C24F [nucleoplasm]
(R-HSA-9663206)
BRCA1 E23Rfs*18 [nucleoplasm]
(R-HSA-9700960)
BRCA1 E23Vfs*17 [nucleoplasm]
(R-HSA-9700967)
p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-5683800)
K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707298)
BRCA1 [nucleoplasm]
(R-HSA-50949)
K6PolyUb-BRCA1 [nucleoplasm]
(R-HSA-9701022)
K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707290)
p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-75234)
0.648
4
UniProt:Q13315 ATM
5
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
ATM [nucleoplasm]
(R-HSA-69484)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [peroxisomal matrix]
(R-HSA-9665169)
ATM [cytosol]
(R-HSA-9665171)
0.623
3
UniProt:O96028-1 NSD2
0.602
3
UniProt:O96028 NSD2
2
p-S102-WHSC1 [nucleoplasm]
(R-HSA-5682984)
WHSC1 [nucleoplasm]
(R-HSA-1183215)
0.591
3
UniProt:Q12888 TP53BP1
3
TP53BP1 [nucleoplasm]
(R-HSA-61175)
SUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
0.577
4
UniProt:Q14676 MDC1
6
SUMO2,3-K1840-MDC1 [nucleoplasm]
(R-HSA-4570473)
SUMO1-K1840-MDC1 [nucleoplasm]
(R-HSA-4570546)
K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684074)
SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684061)
MDC1 [nucleoplasm]
(R-HSA-75231)
p-5T-MDC1 [nucleoplasm]
(R-HSA-75236)
0.564
2
UniProt:Q9BXW9 FANCD2
3
p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6788481)
FANCD2 [nucleoplasm]
(R-HSA-419522)
MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6785318)
0.527
2
UniProt:O76064-1 RNF8
0.524
2
UniProt:Q06609 RAD51
2
p-T309-RAD51 [nucleoplasm]
(R-HSA-5685231)
RAD51 [nucleoplasm]
(R-HSA-62637)
0.524
3
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