MRN complex binds CDK2 and RBBP8

Stable Identifier
R-HSA-5684081
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the S/G2 phase of the cell cycle, CDK2:CCNA (CDK2:cyclin A) complex and CtIP (RBBP8) are recruited to DNA double strand breaks (DSBs) by the MRN complex. RBBP8 interacts with NBN (NBS1) and RAD50 subunits, while CDK2:CCNA interacts with the MRE11A subunit of the complex (Buis et al. 2012). RBBP8 functions as a homotetramer (Davies et al. 2015).

Literature References
PubMed ID Title Journal Year
22231403 Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

Buis, J, Stoneham, T, Spehalski, E, Ferguson, DO

Nat. Struct. Mol. Biol. 2012
25558984 CtIP tetramer assembly is required for DNA-end resection and repair

Davies, OR, Forment, JV, Sun, M, Belotserkovskaya, R, Coates, J, Galanty, Y, Demir, M, Morton, CR, Rzechorzek, NJ, Jackson, SP, Pellegrini, L

Nat. Struct. Mol. Biol. 2015
Participants
Participant Of
Orthologous Events
Authored
Reviewed