Reactome: A Curated Pathway Database

CDK2 phosphorylates RBBP8

Stable Identifier
R-HSA-5684096
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CDK2, in complex with cyclin A (CCNA), phosphorylates RBBP8 (CtIP) on serine residue S327 and threonine residue T847. Residue T847 is conserved in the yeast ortholog of CtIP, Sae2, and phosphorylation of T847 increases CtIP activity in DNA end resection. Serine S327 phosphorylation enables CtIP to bind BRCA1 (Buis et al. 2012).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] protein serine/threonine kinase activity (0004674)
Orthologous Events