Reactome | IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex

IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex

Stable Identifier

R-HSA-5684267

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex

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NFkappaB p105 protein (p105) is a precursor of the NFkappaB p50 subunit and an inhibitor of NFkappaB. The IkappaB kinase (IKK) complex phosphorylates p105 on S927 within the PEST region. TNF-alpha-induced p105 proteolysis additionally requires the phosphorylation of S932. Purified IKK (IKK1) or IKKB (IKK2) can phosphorylate both these regulatory serines in vitro.

Literature References

PubMed ID	Title	Journal	Year
12482991	betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932 Ley, SC, Hay, RT, Janzen, J, Beinke, S, Salmeron, A, Lang, V, Fischer, GZ, Soneji, Y, Ben-Neriah, Y, Allen, H	Mol Cell Biol	2003