The activity of tumor progression locus-2 (TPL2, also known as COT and MAP3K8) is regulated by means of phosphorylation. MAP3K8 undergoes phosphorylated on S400 in its C-terminal tail to activate MAP2Ks (MEK1/2) following LPS stimulation of macrophages. Different experimental systems have suggested that S400 is either autophosphosphorylated by MAPK3P8 (IL-1?-stimulated IL-1R-293T cells) or transphosphorylated by an unknown kinase (LPS-stimulated RAW264.7 macrophages).
Cohen, P, Baltzis, D, McManus, E, Peggie, M, Handoyo, H, Stafford, MJ
Ley, SC, Mambole-Dema, A, Ben-Addi, A, Morrice, N, Roget, K, Abbott, DW, Janzen, J, Yang, HT, Gantke, T
Cohen, P, Morrice, NA, Peggie, MW, Stafford, MJ
IkappaB kinase activity of p-S177,S181-IKKB:IKKA:NEMO [cytosol]
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