Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response
|Mol Biol Cell
Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress
|J. Biol. Chem.
Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
|Nucleic Acids Res.
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
|Mol Cell Biol
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling
Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response
Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1
|Nat Cell Biol