MAPK1/MAPK3 signaling

Stable Identifier
R-HSA-5684996
Type
Pathway
Species
Homo sapiens
Synonyms
ERK1/ERK2 pathway
Locations in the PathwayBrowser
Diagram preview
Summation

The extracellular signal regulated kinases (ERKs) 1 and 2, also known as MAPK3 and MAPK1, are phosphorylated by the MAP2Ks 1 and 2 in response to a wide range of extracellular stimuli to promote differentiation, proliferation, cell motility, cell survivial, metabolism and transcription, among others (reviewed in Roskoski, 2012b; McKay and Morrison, 2007; Raman et al, 2007). In the classical pathway, MAPK1/3 activation is triggered by the GEF-mediated activation of RAS at the plasma membrane, leading to the activation of the RAF MAP3Ks (reviewed in McKay and Morrison, 2007; Matallanas et al, 2011; Wellbrock et al, 2004). However, many physiological and pathological stimuli have been found to activate MAPK1/3 independently of RAF and RAS, acting instead through MAP3Ks such as MOS, TPL2 and AMPK (Dawson et al, 2008; Wang et al, 2009; Kuriakose et al, 2014; Awane et al, 1999). Activated MAPK1/3 phosphorylate numerous targets in both the nucleus and cytoplasm (reviewed in Yoon and Seger, 2006; Roskoski 2012b).

Literature References
PubMed ID Title Journal Year
19520853 A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1

Wang, J, Whiteman, MW, Lian, H, Wang, G, Singh, A, Huang, D, Denmark, T

J. Biol. Chem. 2009
15520807 The RAF proteins take centre stage

Wellbrock, C, Karasarides, M, Marais, R

Nat Rev Mol Cell Biol 2004
18199641 Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway

Dawson, CW, Laverick, L, Morris, MA, Tramoutanis, G, Young, LS

J. Virol. 2008
25378393 Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling

Kuriakose, T, Rada, B, Watford, WT

J. Biol. Chem. 2014
17496909 Differential regulation and properties of MAPKs

Raman, M, Chen, W, Cobb, MH

Oncogene 2007
17496910 Integrating signals from RTKs to ERK/MAPK

McKay, MM, Morrison, DK

Oncogene 2007
16393692 The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

Yoon, S, Seger, R

Growth Factors 2006
10228009 NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells

Awane, M, Andres, PG, Li, DJ, Reinecker, HC

J. Immunol. 1999
22569528 ERK1/2 MAP kinases: structure, function, and regulation

Roskoski, R Jr

Pharmacol. Res. 2012
21779496 Raf family kinases: old dogs have learned new tricks

Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W

Genes Cancer 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed