Reactome | SH2D1A [cytosol]

SH2D1A [cytosol]

Stable Identifier

R-HSA-5685108

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SH2 domain-containing protein 1A, SH21A_HUMAN, SLAM-associated protein (SAP)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60880 SH2D1A

Gene Names

SH2D1A, DSHP, SAP

Chain

chain:1-128

Reference Genes

BioGPS Gene:4068 SH2D1A

COSMIC (genes):SH2D1A SH2D1A

CTD Gene:4068 SH2D1A

dbSNP Gene:4068 SH2D1A

ENSEMBL:ENSG00000183918 SH2D1A

HGNC:10820 SH2D1A

KEGG:hsa:4068 SH2D1A

Monarch:4068 SH2D1A

NCBI Gene:4068 SH2D1A

OMIM:300490 SH2D1A

UCSC:O60880 SH2D1A

Reference Transcript

Participates

as a member of

SAP,EAT2 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000183918

ENSEMBL

ENSP00000477094, ENSP00000353126, ENSP00000513571, ENST00000491950, ENST00000698113, ENST00000360027, ENST00000494073, ENSG00000183918, ENSP00000513588, ENST00000477673, ENSP00000513589, ENSP00000513574, ENST00000371139, ENSP00000513572, ENST00000698116, ENSP00000360181, ENST00000698118

HPA

ENSG00000183918-SH2D1A

GeneCards

SH2D1A

ZINC - Substances

SH21A_HUMAN

ZINC target

O60880

PRO

O60880

Pharos - Targets

O60880

Orphanet

SH2D1A

PDB

1D4T, 1D4W, 1M27, 1D1Z, 1KA7, 1KA6

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96DU3 SLAMF6	1	SLAMF6 [plasma membrane] (R-HSA-197848)	0.868	12
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.866	10
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.556	3
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.556	3
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.547	2
UniProt:O15117 FYB	1	FYB [cytosol] (R-HSA-390925)	0.527	2
UniProt:Q9UIB8 CD84	1	CD84 [plasma membrane] (R-HSA-3325587)	0.527	2
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-5Y-PTK2 [cytosol] (R-HSA-5218711) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.488	2
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.488	2
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.488	2
UniProt:Q99704 DOK1	2	p-Y362-DOK1 [cytosol] (R-HSA-8848784) DOK1 [cytosol] (R-HSA-74763)	0.462	2

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