Reactome | p-S33-RPA2 [nucleoplasm]

p-S33-RPA2 [nucleoplasm]

Stable Identifier

R-HSA-5685148

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
      - HDR through Single Strand Annealing (SSA) (Homo sapiens)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        ATR phosphorylates RPA2 (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        Activation of CHEK1 at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        CHEK1 is recruited to resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
        
        PPP4C:PPP4R2 dephosphorylates RPA2 (Homo sapiens)
        
        p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
        
        p-S33-RPA2 [nucleoplasm] (Homo sapiens)
- Fanconi Anemia Pathway (Homo sapiens)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
    - p-RPA heterotrimer [nucleoplasm] (Homo sapiens)
      - p-S33-RPA2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15927 RPA2

Gene Names

RPA2, REPA2, RPA32, RPA34

Chain

chain:1-270

Reference Genes

BioGPS Gene:6118 RPA2

COSMIC (genes):RPA2 RPA2

CTD Gene:6118 RPA2

dbSNP Gene:6118 RPA2

ENSEMBL:ENSG00000117748 RPA2

HGNC:10290 RPA2

KEGG Gene (Homo sapiens):6118 RPA2

Monarch:6118 RPA2

NCBI Gene:6118 RPA2

OMIM:179836 RPA2

UCSC:P15927 RPA2

Reference Transcript

Other Identifiers

0005890377

1119_at

11717098_a_at

11749574_a_at

11756187_s_at

16684089

201756_at

2403302

2403303

2403304

2403305

2403307

2403308

2403309

2403310

2403311

2403312

2403313

2403314

2403315

2403316

2403317

6118

7914141

A_23_P86133

A_33_P3334635

GE57527

GO:0000082

GO:0000228

GO:0000278

GO:0000723

GO:0000724

GO:0000781

GO:0000784

GO:0000785

GO:0003674

GO:0003677

GO:0003684

GO:0003697

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005662

GO:0005694

GO:0006259

GO:0006260

GO:0006281

GO:0006283

GO:0006284

GO:0006289

GO:0006293

GO:0006294

GO:0006295

GO:0006296

GO:0006297

GO:0006298

GO:0006310

GO:0006950

GO:0006974

GO:0007049

GO:0007165

GO:0008150

GO:0009058

GO:0010569

GO:0016604

GO:0016605

GO:0019899

GO:0019903

GO:0019985

GO:0022607

GO:0031571

GO:0031625

GO:0032201

GO:0032991

GO:0033683

GO:0034502

GO:0034641

GO:0035861

GO:0036297

GO:0042276

GO:0042592

GO:0042769

GO:0043226

GO:0047485

GO:0051276

GO:0065003

GO:0070987

GO:0098505

GO:1900034

GO:1901796

GO:2000001

ILMN_1698510

ILMN_1753582

J05249_at

PH_hs_0004601

TC01002414.hg

g4506584_3p_at

g4506584_3p_x_at

Participant Of

hasComponent

p-RPA heterotrimer [nucleoplasm]

Other forms of this molecule

RPA2 [nucleoplasm]

Inferred To

phospho-RPA2 [nucleoplasm] (Canis familiaris)

phospho-RPA2 [nucleoplasm] (Drosophila melanogaster)

phospho-RPA2 [nucleoplasm] (Gallus gallus)

phospho-RPA2 [nucleoplasm] (Sus scrofa)

phospho-Rpa2 [nucleoplasm] (Mus musculus)

phospho-Rpa2 [nucleoplasm] (Rattus norvegicus)

phospho-rpa2 [nucleoplasm] (Danio rerio)

phospho-rpa2 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 33

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001284487.1, NP_001273005.1, NP_002937.1

Target Pathogen

5b354852be737e166372ebc4

OpenTargets

ENSG00000117748

GeneCards

P15927

HPA

ENSG00000117748-RPA2

Ensembl

ENST00000313433, ENSP00000363015, ENSG00000117748, ENSP00000363021, ENST00000373909, ENST00000373912, ENSP00000363017

PRO

P15927

PDB

1DPU, 4OU0, 2PI2, 1L1O, 2Z6K, 1QUQ, 3KDF, 4MQV, 2PQA, 1Z1D

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27694 RPA1	2	RPA1 [nucleoplasm] (R-HSA-68461) SUMO2,3-K449,K577-RPA1 [nucleoplasm] (R-HSA-4551644)	0.939	12
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.851	8
UniProt:P54132 BLM	2	BLM [nucleoplasm] (R-HSA-174881) 4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883)	0.643	6
UniProt:O75419 CDC45	1	CDC45 [nucleoplasm] (R-HSA-68563)	0.576	4
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q5UIP0 RIF1	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.547	2
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) SUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.491	3
UniProt:P02545 LMNA	3	LMNA-RAF1 fusion [cytosol] (R-HSA-6802399) LMNA(1-664) [nucleoplasm] (R-HSA-535479) p-LMNA-RAF1 fusion [cytosol] (R-HSA-6802537)	0.462	3
UniProt:P51587 BRCA2	2	BRCA2 [nucleoplasm] (R-HSA-50951) p-T3387-BRCA2 [nucleoplasm] (R-HSA-5685241)	0.462	3

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