Reactome: A Curated Pathway Database

CHEK1 phosphorylates BRCA2

Stable Identifier
R-HSA-5685242
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CHEK1 phosphorylates BRCA2 on threonine residue T3887, in the C-terminal region of BRCA2. CHEK1-mediated BRCA2 phosphorylation, as well as CHEK1 mediated RAD51 phosphorylation, promotes the association of BRCA2 with RAD51 (Bahassi et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm] p-S317,S345-CHEK1 [nucleoplasm] protein serine/threonine kinase activity (0004674)
Orthologous Events