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XRCC3 [nucleoplasm]
Stable Identifier
R-HSA-5685303
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA repair protein XRCC3, X-ray repair cross-complementing protein 3
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Homologous DNA Pairing and Strand Exchange (Homo sapiens)
CX3 complex binds D-loop structures (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
CX3 complex formation (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
BLM mediates dissolution of double Holliday junction (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
FIGNL1 binds RAD51 (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
D-loop dissociation and strand annealing (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
CX3 complex [nucleoplasm] (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43542 XRCC3
Gene Names
XRCC3
Chain
chain:1-346
Reference Genes
BioGPS Gene:7517 XRCC3
COSMIC (genes):XRCC3 XRCC3
CTD Gene:7517 XRCC3
dbSNP Gene:7517 XRCC3
ENSEMBL:ENSG00000126215 XRCC3
ENSEMBL_homo_sapiens_GENE:ENSG00000126215.14 XRCC3
HGNC:12830 XRCC3
KEGG Gene (Homo sapiens):7517 XRCC3
Monarch:7517 XRCC3
NCBI Gene:7517 XRCC3
OMIM:600675 XRCC3
Reference Transcript
RefSeq:NM_005432.3 XRCC3
RefSeq:NM_001100118.1 XRCC3
RefSeq:XM_005268046.2 XRCC3
RefSeq:NM_001100119.1 XRCC3
RefSeq:XM_011537138.2 XRCC3
Other Identifiers
11724839_a_at
16797025
216299_PM_s_at
216299_s_at
3580836
3580837
3580838
3580839
3580840
3580845
3580848
3580850
3580852
3580853
3580854
3580855
3580856
3580857
3580858
3580859
3580860
3580861
3580863
3580868
3580870
3580871
3580873
37094_at
7517
7981447
A_23_P48470
A_33_P3301524
GE54284
GO:0000166
GO:0000278
GO:0000400
GO:0000722
GO:0000724
GO:0000781
GO:0003677
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006259
GO:0006281
GO:0006310
GO:0006974
GO:0007010
GO:0007059
GO:0008821
GO:0010033
GO:0010824
GO:0016787
GO:0023052
GO:0032200
GO:0033065
GO:0036297
GO:0043226
GO:0045003
GO:0048471
GO:0071140
GO:0090267
GO:0090656
GO:0090657
GO:0090737
GO:0140014
GO:0140097
GO:0140299
GO:0140657
GO:0140664
HMNXSV003048514
Hs.99742.1.S1_3p_a_at
ILMN_1696266
PH_hs_0034355
TC14001542.hg
Participates
as an input of
CX3 complex formation (Homo sapiens)
as a component of
CX3 complex [nucleoplasm] (Homo sapiens)
Inferred To
Xrcc3 [nucleoplasm]
(Rattus norvegicus)
XRCC3 [nucleoplasm]
(Bos taurus)
XRCC3 [nucleoplasm]
(Canis familiaris)
XRCC3 [nucleoplasm]
(Gallus gallus)
XRCC3 [nucleoplasm]
(Mus musculus)
XRCC3 [nucleoplasm]
(Plasmodium falciparum)
XRCC3 [nucleoplasm]
(Sus scrofa)
xrcc3 [nucleoplasm]
(Danio rerio)
xrcc3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
XP_005268103.1
,
NP_005423.1
,
NP_001093588.1
,
NP_001093589.1
,
XP_011535440.1
OpenTargets
ENSG00000126215
HPA
ENSG00000126215-XRCC3
GeneCards
O43542
Ensembl
ENSP00000451362
,
ENSG00000126215
,
ENST00000554913
,
ENST00000553264
,
ENST00000555055
,
ENST00000352127
,
ENSP00000451974
,
ENSP00000343392
,
ENSP00000452598
PRO
O43542
Pharos - Targets
O43542
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43502 RAD51C
1
RAD51C [nucleoplasm]
(R-HSA-217039)
0.94
12
UniProt:Q06609 RAD51
2
RAD51 [nucleoplasm]
(R-HSA-62637)
p-T309-RAD51 [nucleoplasm]
(R-HSA-5685231)
0.729
5
UniProt:Q9NS69 TOMM22
1
TOMM22 [mitochondrial outer membrane]
(R-HSA-1252180)
0.643
3
UniProt:Q86YC2 PALB2
20
PALB2 Y28C [nucleoplasm]
(R-HSA-9724169)
PALB2 L35P [nucleoplasm]
(R-HSA-9724168)
PALB2 L24S [nucleoplasm]
(R-HSA-9724172)
PALB2 L21A [nucleoplasm]
(R-HSA-9704339)
PALB2 R37H [nucleoplasm]
(R-HSA-9724178)
PALB2 L21F [nucleoplasm]
(R-HSA-9704347)
PALB2 E12* [nucleoplasm]
(R-HSA-9704349)
PALB2 R37C [nucleoplasm]
(R-HSA-9724188)
PALB2 L35F [nucleoplasm]
(R-HSA-9704338)
PALB2 L947F [nucleoplasm]
(R-HSA-9724554)
PALB2 G1043D [nucleoplasm]
(R-HSA-9724584)
PALB2 T1030I [nucleoplasm]
(R-HSA-9704424)
PALB2 T841Qfs*10 [nucleoplasm]
(R-HSA-9704749)
PALB2 L1119P [nucleoplasm]
(R-HSA-9724589)
PALB2 L947S [nucleoplasm]
(R-HSA-9724557)
PALB2 L1143P [nucleoplasm]
(R-HSA-9704428)
PALB2 L1070P [nucleoplasm]
(R-HSA-9724556)
PALB2 C77Vfs*100 [nucleoplasm]
(R-HSA-9704738)
PALB2 L939W [nucleoplasm]
(R-HSA-9704417)
PALB2 L961P [nucleoplasm]
(R-HSA-9724583)
0.577
3
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
UniProt:Q9P296 C5AR2
1
C5AR2 [plasma membrane]
(R-HSA-964798)
0.527
2
UniProt:Q03405 PLAUR
7
PLAUR [endoplasmic reticulum membrane]
(R-HSA-162703)
GPI-PLAUR [endoplasmic reticulum membrane]
(R-HSA-162687)
PLAUR(306-335) [endoplasmic reticulum lumen]
(R-HSA-162707)
PLAUR(23-335) [endoplasmic reticulum membrane]
(R-HSA-162866)
GPI-PLAUR [plasma membrane]
(R-HSA-158946)
PLAUR [plasma membrane]
(R-HSA-6806165)
GPI-PLAUR [specific granule membrane]
(R-HSA-6806143)
0.527
2
UniProt:O14498 ISLR
2
ISLR [extracellular region]
(R-HSA-8848919)
ISLR [platelet alpha granule lumen]
(R-HSA-8848912)
0.527
2
UniProt:P51587 BRCA2
20
BRCA2 D2983Ffs*34 [cytosol]
(R-HSA-9709538)
BRCA2 K2555* [cytosol]
(R-HSA-9711337)
BRCA2 N2553Tfs*95 [cytosol]
(R-HSA-9712872)
BRCA2 T2685Hfs*9 [cytosol]
(R-HSA-9712879)
BRCA2 K2674Rfs*2 [cytosol]
(R-HSA-9712610)
BRCA2 S3231* [cytosol]
(R-HSA-9711458)
BRCA2 I2675Dfs*6 [cytosol]
(R-HSA-9712869)
BRCA2 R2625* [cytosol]
(R-HSA-9711482)
BRCA2 E3071* [cytosol]
(R-HSA-9711354)
BRCA2 V2716Wfs*17 [cytosol]
(R-HSA-9712761)
BRCA2 W2586* [cytosol]
(R-HSA-9711487)
BRCA2 P2767Lfs*10 [cytosol]
(R-HSA-9712509)
BRCA2 K3032* [cytosol]
(R-HSA-9711485)
BRCA2 S2835* [cytosol]
(R-HSA-9711345)
BRCA2 Y3006* [cytosol]
(R-HSA-9711222)
BRCA2 L2926* [cytosol]
(R-HSA-9711348)
BRCA2 R3128* [cytosol]
(R-HSA-9711177)
BRCA2 E2599* [cytosol]
(R-HSA-9711304)
BRCA2 E2571* [cytosol]
(R-HSA-9711560)
BRCA2 Y2977* [cytosol]
(R-HSA-9711182)
0.527
2
UniProt:Q9UQV4 LAMP3
0.527
2
UniProt:Q6NVH7 SWAP1
0.524
2
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