BCDX2 complex stabilizes RAD51 filament

Stable Identifier
R-HSA-5685341
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The BCDX2 complex, composed of RAD51 paralogs RAD51B, RAD51C, RAD51D and XRCC2, preferentially binds at the ends of 3' overhanging ssDNA created by resection of DNA double strand breaks (DSBs). The BCDX2 complex stabilizes nucleoprotein filaments formed by BRCA2-mediated RAD51 loading onto ssDNA (Masson et al. 2001, Chun et al. 2013). The BCDX2 complex may act by inhibiting displacement of RAD51 by BLM helicase (Amunugama et al. 2013).

Literature References
PubMed ID Title Journal Year
11751635 Identification and purification of two distinct complexes containing the five RAD51 paralogs

Masson, JY, Tarsounas, MC, Stasiak, AZ, Stasiak, A, Shah, R, McIlwraith, MJ, Benson, FE, West, SC

Genes Dev. 2001
23149936 Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway

Chun, J, Buechelmaier, ES, Powell, SN

Mol. Cell. Biol. 2013
23810717 The HsRAD51B-HsRAD51C stabilizes the HsRAD51 nucleoprotein filament

Amunugama, R, Groden, J, Fishel, R

DNA Repair (Amst.) 2013
Participants
Participant Of
Orthologous Events
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Reviewed