NCR3LG1 binds NCR3

Stable Identifier
R-HSA-5685602
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NCR3 (NKp30) is one of the natural cytotoxicity receptors (NCRs) expressed mainly on the surface of the natural killer (NK) cells. NKp30 is a major receptor targeting virus-infected cells, malignantly transformed cells, and immature dendritic cells. NCR3 (NKp30) recognizes tumor antigens B7H6, a member of the B7 family (Kaifu et al. 2011, Brandt et al. 2009). B7H6 is not expressed normally, and is found on tumor cells, and sensitizes targets to NCR3-dependent cytotoxicity by NK cells.

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Participant Of
Orthologous Events