NCR3LG1 binds NCR3

Stable Identifier
R-HSA-5685602
Type
Reaction [binding]
Species
Homo sapiens
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NCR3 (NKp30) is one of the natural cytotoxicity receptors (NCRs) expressed mainly on the surface of the natural killer (NK) cells. NKp30 is a major receptor targeting virus-infected cells, malignantly transformed cells, and immature dendritic cells. NCR3 (NKp30) recognizes tumor antigens B7H6, a member of the B7 family (Kaifu et al. 2011, Brandt et al. 2009). B7H6 is not expressed normally, and is found on tumor cells, and sensitizes targets to NCR3-dependent cytotoxicity by NK cells.

Literature References
PubMed ID Title Journal Year
21877119 B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors

Kaifu, T, Escalière, B, Gastinel, LN, Vivier, E, Baratin, M

Cell. Mol. Life Sci. 2011
24305946 BAG-6, a jack of all trades in health and disease

Binici, J, Koch, J

Cell. Mol. Life Sci. 2014
18055229 Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells

Pogge von Strandmann, E, Simhadri, VR, von Tresckow, B, Sasse, S, Reiners, KS, Hansen, HP, Rothe, A, Böll, B, Simhadri, VL, Borchmann, P, McKinnon, PJ, Hallek, M, Engert, A

Immunity 2007
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