SLAMF6 binds SLAMF6

Stable Identifier
R-HSA-5685604
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Members of the signaling lymphocytic-activation molecule (SLAM) family, are all encoded in the SLAM locus, and are mostly homotypic self-associating receptors expressed by cells of hemopoietic origin (Veillette et al. 2006). SLAMF6 (also called as NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses (Cao et al. 2006).

Literature References
PubMed ID Title Journal Year
18031695 Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development

Griewank, K, Borowski, C, Rietdijk, S, Wang, N, Julien, A, Wei, DG, Mamchak, AA, Terhorst, C, Bendelac, A

Immunity 2007
17045824 NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family

Cao, E, Ramagopal, UA, Fedorov, A, Fedorov, E, Yan, Q, Lary, JW, Cole, JL, Nathenson, SG, Almo, SC

Immunity 2006
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created