SLAMF6 binds SLAMF6

Stable Identifier
R-HSA-5685604
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Members of the signaling lymphocytic-activation molecule (SLAM) family, are all encoded in the SLAM locus, and are mostly homotypic self-associating receptors expressed by cells of hemopoietic origin (Veillette et al. 2006). SLAMF6 (also called as NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses (Cao et al. 2006).

Literature References
PubMed ID Title Journal Year
18031695 Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development

Griewank, K, Borowski, C, Rietdijk, S, Wang, N, Julien, A, Wei, DG, Mamchak, AA, Terhorst, C, Bendelac, A

Immunity 2007
17045824 NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family

Cao, E, Ramagopal, UA, Fedorov, A, Fedorov, E, Yan, Q, Lary, JW, Cole, JL, Nathenson, SG, Almo, SC

Immunity 2006
Participants
Participant Of
Orthologous Events
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