SLAMF7 binds SLAMF7

Stable Identifier
R-HSA-5685605
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
CS1 binds CS1
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Signaling Lymphocyte Activation Molecule family member F7 (SLAMF7 also called as CS1 or CRACC) is a member of the CD2 family. It is expressed on CD8+ cytotoxic T lymphocytes, activated B cells, NK cells and mature dendritic cells (Boles & Mathew 2001, Bouchon et al. 2001). It has been suggested that CS1 has both activating and inhibitory functions in NK cells. It may activate NK mediated cytotoxicity through an ERK-mediated pathway in a SAP-independent manner (Bouchon et al. 2001). Most of the CD2 members interact homophilically and CS1 is shown to be a self-ligand and that homophilic interaction regulate NK cell cytolytic activity (Kumaresan et al. 2002).

Literature References
PubMed ID Title Journal Year
23695528 CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes

Kim, JR, Horton, NC, Mathew, SO, Mathew, PA

Inflamm. Res. 2013
12213321 CS1, a novel member of the CD2 family, is homophilic and regulates NK cell function

Kumaresan, PR, Lai, WC, Chuang, SS, Bennett, M, Mathew, PA

Mol. Immunol. 2002
Participants
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