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CLEC2D binds KLRB1
Stable Identifier
R-HSA-5685606
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
CLEC2D binds KLRB1 (Homo sapiens)
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Natural killer cell surface protein P1A (NKRP1A or KLRB1 or CD161) receptor is a lectin like surface molecule expressed as a type II disulphide-linked homodimer on natural killer (NK) cells and subsets of T cells (Lknair et al. 1994, Mesci et al. 2006). Its expression is upregulated on mature NK cells by interleukin-12 (Poggi et al. 2007). It is thought to be involved in the regulation of NK and NKT cell function. Lectin-like transcript-1 molecule (LLT1) (also referred to as CLEC2D) a member of the KLR (killer cell lectin-like receptor) family has been identified as a ligand for the human NKRP1A (Aldemir et al. 2005, Rosen et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
16339513
Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor
Rosen, DB
,
Mathew, PA
,
Warren, HS
,
Lanier, LL
,
Alsharifi, M
,
Bettadapura, J
J. Immunol.
2005
Participants
Input
CLEC2D dimer [plasma membrane]
(Homo sapiens)
KLRB1 dimer [plasma membrane]
(Homo sapiens)
Output
CLEC2D dimer:KLRB1 dimer [plasma membrane]
(Homo sapiens)
Entity On Other Cell
CLEC2D [plasma membrane]
(Homo sapiens)
Participates
as an event of
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
Orthologous Events
CLEC2D binds KLRB1 (Canis familiaris)
CLEC2D binds KLRB1 (Sus scrofa)
Authored
Garapati, P V (2015-03-27)
Reviewed
Barrow, AD (2015-05-13)
Created
Garapati, P V (2015-03-27)
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