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HDR through Homologous Recombination (HRR)
Stable Identifier
R-HSA-5685942
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
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Homology directed repair (HDR) through homologous recombination is known as homologous recombination repair (HRR). HRR occurs after extensive resection of DNA double-strand break (DSB) ends, which creates long 3'-ssDNA overhangs. RAD51 coats 3'-ssDNA overhangs in a BRCA2-controlled fashion, creating invasive RAD51 nucleofilaments. The RAD51 nucleofilament invades a sister chromatid DNA duplex, leading to D-loop formation. After the D-loop is extended by DNA repair synthesis, the resulting recombination intermediates in the form of extended D-loops or double Holliday junctions can be resolved through crossover- or non-crossover-generating processes (reviewed by Ciccia and Elledge 2010).
Literature References
PubMed ID
Title
Journal
Year
20965415
The DNA damage response: making it safe to play with knives
Elledge, SJ
,
Ciccia, A
Mol. Cell
2010
Participants
Events
Homologous DNA Pairing and Strand Exchange
(Homo sapiens)
D-loop extension by DNA polymerases
(Homo sapiens)
Resolution of D-Loop Structures
(Homo sapiens)
Participates
as an event of
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
Orthologous Events
HDR through Homologous Recombination (HRR) (Bos taurus)
HDR through Homologous Recombination (HRR) (Caenorhabditis elegans)
HDR through Homologous Recombination (HRR) (Canis familiaris)
HDR through Homologous Recombination (HRR) (Danio rerio)
HDR through Homologous Recombination (HRR) (Drosophila melanogaster)
HDR through Homologous Recombination (HRR) (Gallus gallus)
HDR through Homologous Recombination (HRR) (Mus musculus)
HDR through Homologous Recombination (HRR) (Plasmodium falciparum)
HDR through Homologous Recombination (HRR) (Rattus norvegicus)
HDR through Homologous Recombination (HRR) (Saccharomyces cerevisiae)
HDR through Homologous Recombination (HRR) (Schizosaccharomyces pombe)
HDR through Homologous Recombination (HRR) (Sus scrofa)
HDR through Homologous Recombination (HRR) (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000939
Authored
Orlic-Milacic, M (2015-05-12)
Reviewed
Borowiec, JA (2015-06-12)
Created
Orlic-Milacic, M (2015-03-30)
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