Reactome: A Curated Pathway Database

HDR through Homologous Recombination (HRR)

Stable Identifier
R-HSA-5685942
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Homology directed repair (HDR) through homologous recombination is known as homologous recombination repair (HRR). HRR occurs after extensive resection of DNA double strand break (DSB) ends, which creates long 3'-ssDNA overhangs. RAD51 coats 3'-ssDNA overhangs in a BRCA2-controlled fashion, creating invasive RAD51 nucleofilaments. The RAD51 nucleofilament invades a sister chromatid DNA duplex, leading to D-loop formation. After the D-loop is extended by DNA repair synthesis, the resulting recombination intermediates in the form of extended D-loops or double Holliday junctions can be resolved through crossover- or non-crossover-generating processes (reviewed by Ciccia and Elledge 2010).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events