HDR through Homologous Recombination (HRR)

Stable Identifier
R-HSA-5685942
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Homology directed repair (HDR) through homologous recombination is known as homologous recombination repair (HRR). HRR occurs after extensive resection of DNA double-strand break (DSB) ends, which creates long 3'-ssDNA overhangs. RAD51 coats 3'-ssDNA overhangs in a BRCA2-controlled fashion, creating invasive RAD51 nucleofilaments. The RAD51 nucleofilament invades a sister chromatid DNA duplex, leading to D-loop formation. After the D-loop is extended by DNA repair synthesis, the resulting recombination intermediates in the form of extended D-loops or double Holliday junctions can be resolved through crossover- or non-crossover-generating processes (reviewed by Ciccia and Elledge 2010).
Literature References
PubMed ID Title Journal Year
20965415 The DNA damage response: making it safe to play with knives

Elledge, SJ, Ciccia, A

Mol. Cell 2010
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