There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

SIRT6 deacetylates RBBP8

Stable Identifier
R-HSA-5685953
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RBBP8 (CtIP) is constitutively acetylated in the absence of DNA damage on lysine residues K432, K526 and K604, and perhaps other lysines. DNA damage, through an unknown mechanism, triggers deacetylation of RBBP8 by SIRT6 protein lysine deacetylase. SIRT6-mediated deacetylation of RBBP8 is necessary for RBBP8-promoted resection of DNA double strand breaks (DSBs) (Kaidi et al. 2010).

Literature References
PubMed ID Title Journal Year
20829486 Human SIRT6 promotes DNA end resection through CtIP deacetylation Science 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD-dependent protein deacetylase activity of SIRT6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events