Reactome: A Curated Pathway Database

SIRT6 deacetylates RBBP8

Stable Identifier
R-HSA-5685953
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RBBP8 (CtIP) is constitutively acetylated in the absence of DNA damage on lysine residues K432, K526 and K604, and perhaps other lysines. DNA damage, through an unknown mechanism, triggers deacetylation of RBBP8 by SIRT6 protein lysine deacetylase. SIRT6-mediated deacetylation of RBBP8 is necessary for RBBP8-promoted resection of DNA double strand breaks (DSBs) (Kaidi et al. 2010).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
NAD-dependent protein deacetylase activity of SIRT6 [nucleoplasm] SIRT6 [nucleoplasm] NAD-dependent protein deacetylase activity (0034979)
Orthologous Events