Reactome | SIRT6 [nucleoplasm]

SIRT6 [nucleoplasm]

Stable Identifier

R-HSA-5685963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NAD-dependent protein deacetylase sirtuin-6, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIR2L6

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        SIRT6 deacetylates RBBP8 (Homo sapiens)
        
        SIRT6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N6T7 SIRT6

Gene Names

SIRT6, SIR2L6

Chain

initiator methionine:1, chain:2-355

Reference Genes

BioGPS Gene:51548 SIRT6

COSMIC (genes):SIRT6 SIRT6

CTD Gene:51548 SIRT6

dbSNP Gene:51548 SIRT6

ENSEMBL:ENSG00000077463 SIRT6

HGNC:14934 SIRT6

KEGG Gene (Homo sapiens):51548 SIRT6

Monarch:51548 SIRT6

NCBI Gene:51548 SIRT6

OMIM:606211 SIRT6

UCSC:Q8N6T7 SIRT6

Reference Transcript

Other Identifiers

0002480441

11719390_a_at

11763722_x_at

16867260

219613_s_at

233179_3p_x_at

233179_x_at

3846668

3846669

3846670

3846672

3846673

3846675

3846677

3846679

3846680

3846682

3846684

3846685

51548

56827_at

8032770

A_23_P208847

GE54998

GO:0000122

GO:0003247

GO:0003674

GO:0003714

GO:0003950

GO:0003956

GO:0004407

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006259

GO:0006464

GO:0006471

GO:0006476

GO:0006950

GO:0008150

GO:0008270

GO:0008283

GO:0009056

GO:0009058

GO:0010569

GO:0016740

GO:0016757

GO:0016810

GO:0017136

GO:0019213

GO:0022607

GO:0030154

GO:0031667

GO:0031940

GO:0032206

GO:0033558

GO:0034641

GO:0034979

GO:0040007

GO:0042592

GO:0043167

GO:0043226

GO:0046872

GO:0046969

GO:0048646

GO:0048856

GO:0051276

GO:0061647

GO:0070403

GO:0070932

GO:0099115

GO:0120162

GO:1901485

GO:1902732

GO:1905549

GO:1905555

GO:1905564

GO:1990619

HMNXSV003007913

HMNXSV003047903

Hs.105463.3.A1_3p_a_at

ILMN_1654246

PH_hs_0019790

TC19001059.hg

g7706709_3p_a_at

Participates

as an input of

SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)

as a component of

Inferred To

SIRT6 [nucleoplasm] (Bos taurus)

SIRT6 [nucleoplasm] (Canis familiaris)

SIRT6 [nucleoplasm] (Gallus gallus)

SIRT6 [nucleoplasm] (Sus scrofa)

sirt6 [nucleoplasm] (Danio rerio)

sir-2.4 [nucleoplasm] (Caenorhabditis elegans)

Sirt6 [nucleoplasm] (Mus musculus)

Sirt6 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001307989.1, NP_001307991.1, NP_057623.2, NP_001307990.1, NP_001307988.1, NP_001307993.1, NP_001180214.1, NP_001307987.1, NP_001307992.1

OpenTargets

ENSG00000077463

IntEnz

2.3.1.286

GeneCards

Q8N6T7

HPA

ENSG00000077463-SIRT6

Ensembl

ENSP00000337332, ENSG00000077463, ENST00000337491, ENST00000305232, ENSP00000305310

ZINC target

Q8N6T7

PRO

Q8N6T7

Orphanet

29235

HMDB Protein

HMDBP00903

PDB

3ZG6, 6XV1, 5Y2F, 5MFZ, 6QCE, 6QCH, 6XV6, 3PKI, 6XVG, 3K35, 5MFP, 5X16, 5MF6, 6HOY, 6QCD, 5MGN, 6QCJ, 3PKJ, 6XUY

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-15576911 H3(413)			0.618	3
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.602	4
UniProt:Q12873 CHD3	2	SUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372) CHD3 [nucleoplasm] (R-HSA-4657012)	0.553	2
UniProt:P08670 VIM	11	VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.553	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.524	3