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SIRT6 [nucleoplasm]
Stable Identifier
R-HSA-5685963
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NAD-dependent protein deacetylase sirtuin-6, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIR2L6
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
SIRT6 deacetylates RBBP8 (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH1,NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH1,NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N6T7 SIRT6
Gene Names
SIRT6, SIR2L6
Chain
initiator methionine:, chain:2-355
Reference Genes
BioGPS Gene:51548 SIRT6
COSMIC (genes):SIRT6 SIRT6
CTD Gene:51548 SIRT6
dbSNP Gene:51548 SIRT6
ENSEMBL:ENSG00000077463 SIRT6
ENSEMBL_homo_sapiens_GENE:ENSG00000077463.15 SIRT6
HGNC:14934 SIRT6
KEGG Gene (Homo sapiens):51548 SIRT6
Monarch:51548 SIRT6
NCBI Gene:51548 SIRT6
OMIM:606211 SIRT6
UCSC:Q8N6T7 SIRT6
Reference Transcript
RefSeq:NM_001321062.1 SIRT6
RefSeq:NM_001193285.2 SIRT6
RefSeq:NM_001321064.1 SIRT6
RefSeq:NM_001321059.1 SIRT6
RefSeq:NM_001321061.1 SIRT6
RefSeq:NM_001321058.1 SIRT6
RefSeq:NM_001321063.1 SIRT6
RefSeq:NM_001321060.1 SIRT6
RefSeq:NM_016539.3 SIRT6
Other Identifiers
11719390_a_at
11763722_x_at
16867260
219613_PM_s_at
219613_s_at
233179_3p_x_at
233179_PM_x_at
233179_x_at
3846668
3846669
3846670
3846672
3846673
3846675
3846677
3846679
3846680
3846682
3846684
3846685
51548
56827_at
8032770
A_23_P208847
GE54998
GO:0000122
GO:0000781
GO:0000785
GO:0003677
GO:0003682
GO:0003684
GO:0003714
GO:0003723
GO:0003824
GO:0003950
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005721
GO:0005783
GO:0005975
GO:0006091
GO:0006281
GO:0006284
GO:0006302
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006476
GO:0006629
GO:0006886
GO:0006913
GO:0006974
GO:0008270
GO:0008285
GO:0008340
GO:0009411
GO:0010526
GO:0010569
GO:0016740
GO:0016746
GO:0016757
GO:0016779
GO:0016787
GO:0017136
GO:0019216
GO:0023052
GO:0030154
GO:0030163
GO:0031047
GO:0031490
GO:0031491
GO:0031508
GO:0031509
GO:0031648
GO:0032024
GO:0032200
GO:0032206
GO:0032436
GO:0032922
GO:0033558
GO:0034244
GO:0034979
GO:0035861
GO:0036211
GO:0042181
GO:0042308
GO:0042593
GO:0042752
GO:0042803
GO:0043226
GO:0043231
GO:0043687
GO:0045600
GO:0045721
GO:0045814
GO:0045820
GO:0045892
GO:0046325
GO:0046827
GO:0046872
GO:0046969
GO:0048146
GO:0048856
GO:0050708
GO:0050994
GO:0051697
GO:0055007
GO:0055085
GO:0055086
GO:0065003
GO:0070403
GO:0072659
GO:0090734
GO:0097372
GO:0099115
GO:0106222
GO:0106274
GO:0120162
GO:0120186
GO:0120187
GO:0140096
GO:0140110
GO:0140299
GO:0140612
GO:0140765
GO:0140773
GO:0140774
GO:0140804
GO:0140861
GO:1901135
GO:1902459
GO:1902732
GO:1903076
GO:1904841
GO:1905555
GO:1905564
GO:1990166
GO:1990404
GO:2000648
GO:2000738
GO:2000773
GO:2000781
HMNXSV003007913
HMNXSV003047903
Hs.105463.3.A1_3p_a_at
ILMN_1654246
PH_hs_0019790
TC19001059.hg
g7706709_3p_a_at
Participates
as an input of
SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
as a component of
SIRT6:Nucleosome(H3K9ac):NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH4 gene [nucleoplasm] (Homo sapiens)
Inferred To
SIRT6 [nucleoplasm]
(Bos taurus)
SIRT6 [nucleoplasm]
(Caenorhabditis elegans)
SIRT6 [nucleoplasm]
(Canis familiaris)
SIRT6 [nucleoplasm]
(Danio rerio)
SIRT6 [nucleoplasm]
(Gallus gallus)
SIRT6 [nucleoplasm]
(Mus musculus)
SIRT6 [nucleoplasm]
(Rattus norvegicus)
SIRT6 [nucleoplasm]
(Sus scrofa)
SIRT6 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001307991.1
,
NP_001180214.1
,
NP_001307989.1
,
NP_001307987.1
,
NP_001307992.1
,
NP_001307988.1
,
NP_001307990.1
,
NP_001307993.1
,
NP_057623.2
Guide to Pharmacology - Targets
2712
OpenTargets
ENSG00000077463
ZINC target
Q8N6T7
PRO
Q8N6T7
PDB
6HOY
,
8AK7
,
8AKE
,
8G57
,
5MFZ
,
8AKF
,
6XV1
,
8AK5
,
5MGN
,
8AKC
,
6XV6
,
8I2B
,
8AK6
,
6QCD
,
8AKD
,
5MF6
,
5MFP
,
5X16
,
7CL0
,
8F86
,
8BL0
,
7CL1
,
3PKI
,
6QCJ
,
6ZU4
,
8BL1
,
8AKA
,
3K35
,
8OF4
,
8AKB
,
5Y2F
,
6XUY
,
8AK8
,
6QCE
,
8AKG
,
8CNM
,
6XVG
,
8AK9
,
8CNO
,
3ZG6
,
6QCH
,
3PKJ
IntEnz
2.3.1.286
HPA
ENSG00000077463-SIRT6
GeneCards
Q8N6T7
Ensembl
ENSG00000077463
,
ENSP00000337332
,
ENSP00000305310
,
ENST00000337491
,
ENST00000305232
Pharos - Targets
Q8N6T7
Orphanet
29235
HMDB Protein
HMDBP00903
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-15576911 H3(413)
0.618
3
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.602
4
UniProt:Q12873 CHD3
2
CHD3 [nucleoplasm]
(R-HSA-4657012)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
0.553
2
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.553
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.524
3
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