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SIRT6 [nucleoplasm]
Stable Identifier
R-HSA-5685963
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NAD-dependent protein deacetylase sirtuin-6, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIR2L6
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
SIRT6 deacetylates RBBP8 (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH1,NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH1,NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N6T7 SIRT6
Gene Names
SIRT6, SIR2L6
Chain
initiator methionine:1, chain:2-355
Reference Genes
BioGPS Gene:51548 SIRT6
COSMIC (genes):SIRT6 SIRT6
CTD Gene:51548 SIRT6
dbSNP Gene:51548 SIRT6
ENSEMBL:ENSG00000077463 SIRT6
HGNC:14934 SIRT6
KEGG Gene (Homo sapiens):51548 SIRT6
Monarch:51548 SIRT6
NCBI Gene:51548 SIRT6
OMIM:606211 SIRT6
UCSC:Q8N6T7 SIRT6
Reference Transcript
RefSeq:NM_001321062.1 SIRT6
RefSeq:NM_001321058.1 SIRT6
RefSeq:NM_001321059.1 SIRT6
RefSeq:NM_001321064.1 SIRT6
RefSeq:NM_001321060.1 SIRT6
RefSeq:NM_016539.3 SIRT6
RefSeq:NM_001193285.2 SIRT6
RefSeq:NM_001321061.1 SIRT6
RefSeq:NM_001321063.1 SIRT6
Other Identifiers
0002480441
11719390_a_at
11763722_x_at
16867260
219613_s_at
233179_3p_x_at
233179_x_at
3846668
3846669
3846670
3846672
3846673
3846675
3846677
3846679
3846680
3846682
3846684
3846685
51548
56827_at
8032770
A_23_P208847
GE54998
GO:0000122
GO:0003247
GO:0003674
GO:0003714
GO:0003950
GO:0003956
GO:0004407
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006259
GO:0006464
GO:0006471
GO:0006476
GO:0006950
GO:0008150
GO:0008270
GO:0008283
GO:0009056
GO:0009058
GO:0010569
GO:0016740
GO:0016757
GO:0016810
GO:0017136
GO:0019213
GO:0022607
GO:0030154
GO:0031667
GO:0031940
GO:0032206
GO:0033558
GO:0034641
GO:0034979
GO:0040007
GO:0042592
GO:0043167
GO:0043226
GO:0046872
GO:0046969
GO:0048646
GO:0048856
GO:0051276
GO:0061647
GO:0070403
GO:0070932
GO:0099115
GO:0120162
GO:1901485
GO:1902732
GO:1905549
GO:1905555
GO:1905564
GO:1990619
HMNXSV003007913
HMNXSV003047903
Hs.105463.3.A1_3p_a_at
ILMN_1654246
PH_hs_0019790
TC19001059.hg
g7706709_3p_a_at
Participates
as an input of
SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)
as a component of
SIRT6:Nucleosome(H3K9ac):NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome(H3K9ac):NOTCH4 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH1 gene [nucleoplasm] (Homo sapiens)
SIRT6:Nucleosome:NOTCH4 gene [nucleoplasm] (Homo sapiens)
Inferred To
SIRT6 [nucleoplasm]
(Bos taurus)
SIRT6 [nucleoplasm]
(Canis familiaris)
SIRT6 [nucleoplasm]
(Gallus gallus)
SIRT6 [nucleoplasm]
(Sus scrofa)
sirt6 [nucleoplasm]
(Danio rerio)
sir-2.4 [nucleoplasm]
(Caenorhabditis elegans)
Sirt6 [nucleoplasm]
(Mus musculus)
Sirt6 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001307989.1
,
NP_001307991.1
,
NP_057623.2
,
NP_001307990.1
,
NP_001307988.1
,
NP_001307993.1
,
NP_001180214.1
,
NP_001307987.1
,
NP_001307992.1
OpenTargets
ENSG00000077463
IntEnz
2.3.1.286
GeneCards
Q8N6T7
HPA
ENSG00000077463-SIRT6
Ensembl
ENSP00000337332
,
ENSG00000077463
,
ENST00000337491
,
ENST00000305232
,
ENSP00000305310
ZINC target
Q8N6T7
PRO
Q8N6T7
Orphanet
29235
HMDB Protein
HMDBP00903
PDB
3ZG6
,
6XV1
,
5Y2F
,
5MFZ
,
6QCE
,
6QCH
,
6XV6
,
3PKI
,
6XVG
,
3K35
,
5MFP
,
5X16
,
5MF6
,
6HOY
,
6QCD
,
5MGN
,
6QCJ
,
3PKJ
,
6XUY
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-15576911 H3(413)
0.618
3
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
SUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.602
4
UniProt:Q12873 CHD3
2
SUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
CHD3 [nucleoplasm]
(R-HSA-4657012)
0.553
2
UniProt:P08670 VIM
11
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.553
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.524
3
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