Reactome | SIRT6 [nucleoplasm]

SIRT6 [nucleoplasm]

Stable Identifier

R-HSA-5685963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NAD-dependent protein deacetylase sirtuin-6, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIR2L6

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        SIRT6 deacetylates RBBP8 (Homo sapiens)
        
        SIRT6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N6T7 SIRT6

Gene Names

SIRT6, SIR2L6

Chain

initiator methionine:, chain:2-355

Reference Genes

BioGPS Gene:51548 SIRT6

COSMIC (genes):SIRT6 SIRT6

CTD Gene:51548 SIRT6

dbSNP Gene:51548 SIRT6

ENSEMBL:ENSG00000077463 SIRT6

HGNC:14934 SIRT6

KEGG:hsa:51548 SIRT6

Monarch:51548 SIRT6

NCBI Gene:51548 SIRT6

OMIM:606211 SIRT6

UCSC:Q8N6T7 SIRT6

Reference Transcript

Other Identifiers

11719390_a_at

11761279_a_at

11761730_a_at

11761731_x_at

11763722_x_at

16867260

219613_PM_s_at

219613_s_at

233179_3p_x_at

233179_PM_x_at

233179_x_at

3846668

3846669

3846670

3846671

3846672

3846673

3846674

3846675

3846676

3846677

3846679

3846680

3846681

3846682

3846683

3846684

3846685

3846686

51548

56827_at

8032770

A_23_P208847

GE54998

GO:0000122

GO:0000781

GO:0000785

GO:0003677

GO:0003682

GO:0003684

GO:0003714

GO:0003723

GO:0003824

GO:0003950

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005721

GO:0005783

GO:0006281

GO:0006284

GO:0006302

GO:0006325

GO:0006338

GO:0006355

GO:0006476

GO:0006606

GO:0006886

GO:0006913

GO:0008270

GO:0008285

GO:0008340

GO:0009411

GO:0010526

GO:0010569

GO:0016740

GO:0016746

GO:0016757

GO:0016779

GO:0016787

GO:0017136

GO:0019216

GO:0030154

GO:0030234

GO:0031490

GO:0031491

GO:0031508

GO:0031509

GO:0031648

GO:0032024

GO:0032041

GO:0032129

GO:0032206

GO:0032436

GO:0032922

GO:0034244

GO:0034979

GO:0035033

GO:0035861

GO:0042181

GO:0042308

GO:0042593

GO:0042752

GO:0042803

GO:0043226

GO:0043231

GO:0043687

GO:0045600

GO:0045721

GO:0045814

GO:0045820

GO:0045892

GO:0046325

GO:0046827

GO:0046872

GO:0046969

GO:0046970

GO:0048146

GO:0050708

GO:0050994

GO:0051697

GO:0055007

GO:0060090

GO:0070403

GO:0090734

GO:0097372

GO:0098772

GO:0099115

GO:0106222

GO:0106274

GO:0120162

GO:0120186

GO:0120187

GO:0140096

GO:0140110

GO:0140299

GO:0140612

GO:0140765

GO:0140773

GO:0140774

GO:0140804

GO:0140861

GO:0141222

GO:1902459

GO:1902732

GO:1903076

GO:1904841

GO:1905555

GO:1905564

GO:1990166

GO:1990404

GO:2000648

GO:2000738

GO:2000773

GO:2000781

HMNXSV003007913

HMNXSV003047903

Hs.105463.3.A1_3p_a_at

Hs.105463.3.A1_3p_at

Hs.105463.3.A1_3p_x_at

ILMN_1654246

PH_hs_0019790

TC19001059.hg

g7706709_3p_a_at

Participates

as an input of

SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)

as a component of

Inferred To

SIRT6 [nucleoplasm] (Bos taurus)

SIRT6 [nucleoplasm] (Canis familiaris)

SIRT6 [nucleoplasm] (Gallus gallus)

SIRT6 [nucleoplasm] (Sus scrofa)

sirt6 [nucleoplasm] (Danio rerio)

sirt6 [nucleoplasm] (Xenopus tropicalis)

sir-2.4 [nucleoplasm] (Caenorhabditis elegans)

Sirt6 [nucleoplasm] (Mus musculus)

Sirt6 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001307990.1, NP_001307987.1, NP_001307992.1, NP_001307991.1, NP_001307988.1, NP_001307989.1, NP_057623.2, NP_001180214.1, NP_001307993.1

Guide to Pharmacology - Targets

2712

OpenTargets

ENSG00000077463

ENSEMBL

ENST00000337491, ENST00000305232, ENSG00000077463, ENSP00000305310, ENSP00000337332

ZINC - Substances

SIR6_HUMAN

ZINC target

Q8N6T7

PRO

Q8N6T7

PDB

9G7H, 5MGN, 8AKA, 8AK9, 8AK7, 8CNO, 5MFZ, 6XUY, 3K35, 8OF4, 3PKI, 6XVG, 7CL1, 8AK5, 8AK8, 8G57, 3ZG6, 3PKJ, 8AK6, 6QCE, 5MFP, 6HOY, 6XV1, 6QCH, 5Y2F, 8CNM, 7CL0, 6QCD, 6QCJ, 6XV6, 8BL1, 8BL0, 8AKG, 8I2B, 5X16, 8AKC, 6ZU4, 8AKE, 8AKB, 5MF6, 8AKF, 8AKD, 8F86

IntEnz

2.3.1.286

HPA

ENSG00000077463-SIRT6

GeneCards

SIRT6

Pharos - Targets

Q8N6T7

Orphanet

SIRT6

HMDB Protein

HMDBP00903

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-15576911 H3(413)			0.618	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.602	4
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.553	2
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.553	2
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.527	2
UniProt:Q7Z5L9 I2BP2			0.527	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.524	3