p-3Y-SHC1 dissociates from IGF1R

Stable Identifier
R-HSA-5686072
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Release of tyrosine-phosphorylated SHC from IGF1R triggers a cascade of signalling events via SOS, RAF and the MAP kinases.
Literature References
PubMed ID Title Journal Year
8033892 Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor

Pelicci, G, Pelicci, PG, Van Obberghen, E, Giorgetti, S

Eur. J. Biochem. 1994
9852124 Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling

Feldman, EL, Cheng, HL, Margolis, B, Kim, B

J. Biol. Chem. 1998
7493944 The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis

Kalebic, T, Blakesley, V, LeRoith, D, Hernández-Sánchez, C, Helman, L

J. Biol. Chem. 1995
Participants
Participates
Orthologous Events
Authored
Created
Cite Us!