The palmitoyltransferase ZDHHC2 transfers a palmitoyl group (PALM) from the high energy donor palmitoyl-CoA (PALM-CoA) to cytoskeleton-associated protein 4 (CKAP4 aka p63). CKAP4 is thought to be a surfactant A binding protein on the surface of alveolar type II epithelial cells where it plays a role in bridging the plasma membrane to the cytoskeleton and in the reuptake of surfactant A. CKAP4 palmitoylation on the cysteine 100 residue by DHHC2 is required for its trafficking from the ER to the plasma membrane (Schweizer et al. 1993, Planey et al. 2009).
Planey, SL, Keay, SK, Zhang, CO, Zacharias, DA
Schweizer, A, Rohrer, J, Jenö, P, DeMaio, A, Buchman, TG, Hauri, HP
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