SPIDR binds BLM:TOP3A:RMI1:RMI2

Stable Identifier
R-HSA-5686398
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SPIDR binds BLM:TOP3A:RMI1:RMI2
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SPIDR binds the BTRR complex (BLM:TOP3A:RMI1:RMI2) through a direct interaction with BLM. SPIDR also interacts with RAD51, thereby connecting the BTRR complex with Holliday Junctions (Wan et al. 2013).
Literature References
PubMed ID Title Journal Year
23509288 Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

Chen, H, Huang, J, Liu, T, Han, J, Dong, S, Wan, L, Xie, F

Proc. Natl. Acad. Sci. U.S.A. 2013
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Orthologous Events
SPIDR binds BLM:TOP3A:RMI1:RMI2 (Bos taurus)
SPIDR binds BLM:TOP3A:RMI1:RMI2 (Gallus gallus)
SPIDR binds BLM:TOP3A:RMI1:RMI2 (Mus musculus)
SPIDR binds BLM:TOP3A:RMI1:RMI2 (Rattus norvegicus)
SPIDR binds BLM:TOP3A:RMI1:RMI2 (Sus scrofa)
SPIDR binds BLM:TOP3A:RMI1:RMI2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-04-01)
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