MUS81 binds EME1 (MMS4) to form an evolutionarily conserved endonuclease complex involved in processing of aberrant replication intermediates and the cleavage of homologous recombination intermediates (Ciccia et al. 2003, Ogrunc and Sancar 2003). MUS81 can also form an endonuclease complex with EME2. EME2 is 40% identical to EME1 at the amino acid level and the MUS81:EME2 complex likely functions in a similar way to the MUS81:EME1 complex (Ciccia et al. 2007).
Laghmani, el H,
de Winter, JP,