Reactome | EME1 [nucleoplasm]

EME1 [nucleoplasm]

Stable Identifier

R-HSA-5686437

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Crossover junction endonuclease EME1, MMS4

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2),GEN1 [nucleoplasm] (Homo sapiens)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1 [nucleoplasm] (Homo sapiens)
        
        EME1 [nucleoplasm] (Homo sapiens)
        
        MUS81 binds EME1, EME2 (Homo sapiens)
        
        EME1,EME2 [nucleoplasm] (Homo sapiens)
        
        EME1 [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1 [nucleoplasm] (Homo sapiens)
        
        EME1 [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1 [nucleoplasm] (Homo sapiens)
        
        EME1 [nucleoplasm] (Homo sapiens)
        
        SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1 [nucleoplasm] (Homo sapiens)
        
        EME1 [nucleoplasm] (Homo sapiens)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1 [nucleoplasm] (Homo sapiens)
        
        EME1 [nucleoplasm] (Homo sapiens)
- Fanconi Anemia Pathway (Homo sapiens)
  - DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
      - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1 [nucleoplasm] (Homo sapiens)
        
        EME1 [nucleoplasm] (Homo sapiens)
    - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
      - MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1 [nucleoplasm] (Homo sapiens)
        
        EME1 [nucleoplasm] (Homo sapiens)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
      - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1 [nucleoplasm] (Homo sapiens)
        
        EME1 [nucleoplasm] (Homo sapiens)
    - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
      - MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1 [nucleoplasm] (Homo sapiens)
        
        EME1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96AY2 EME1

Gene Names

EME1, MMS4

Chain

chain:1-570

Reference Genes

BioGPS Gene:146956 EME1

COSMIC (genes):EME1 EME1

CTD Gene:146956 EME1

dbSNP Gene:146956 EME1

ENSEMBL:ENSG00000154920 EME1

ENSEMBL_homo_sapiens_GENE:ENSG00000154920.15 EME1

HGNC:24965 EME1

KEGG Gene (Homo sapiens):146956 EME1

Monarch:146956 EME1

NCBI Gene:146956 EME1

OMIM:610885 EME1

UCSC:Q96AY2 EME1

Reference Transcript

Other Identifiers

11727941_a_at

146956

16835797

234464_PM_s_at

234464_s_at

234465_PM_at

234465_at

3726376

3726377

3726378

3726379

3726381

3726382

3726383

3726384

3726385

3726387

3726388

3726389

3726391

3726392

3726393

3726394

8008310

A_14_P104142

A_23_P368225

GO:0000228

GO:0000278

GO:0000712

GO:0000785

GO:0000792

GO:0003677

GO:0003824

GO:0004518

GO:0004519

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006260

GO:0006281

GO:0006302

GO:0006310

GO:0006974

GO:0007059

GO:0008821

GO:0016787

GO:0022414

GO:0023052

GO:0031297

GO:0031573

GO:0043226

GO:0043596

GO:0046872

GO:0048476

GO:0072429

GO:0140013

GO:0140097

GO:1905347

HMNXSV003043820

Hs.283558.3.S1_3p_a_at

Hs.283558.3.S1_3p_x_at

ILMN_1750102

PH_hs_0020999

TC17000664.hg

Participates

as a member of

EME1,EME2 [nucleoplasm] (Homo sapiens)

as a component of

MUS81:EME1 [nucleoplasm] (Homo sapiens)

Inferred To

Eme1 [nucleoplasm] (Mus musculus)

Eme1 [nucleoplasm] (Rattus norvegicus)

eme1 [nucleoplasm] (Danio rerio)

eme1 [nucleoplasm] (Schizosaccharomyces pombe)

eme1 [nucleoplasm] (Xenopus tropicalis)

EME1 [nucleoplasm] (Bos taurus)

EME1 [nucleoplasm] (Canis familiaris)

EME1 [nucleoplasm] (Gallus gallus)

EME1 [nucleoplasm] (Sus scrofa)

MMS4 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_689676.2, NP_001159603.1

OpenTargets

ENSG00000154920

HPA

ENSG00000154920-EME1

GeneCards

Q96AY2

Ensembl

ENSP00000421700, ENSG00000154920, ENST00000393271, ENST00000511648, ENSP00000376952, ENSP00000339897, ENST00000338165

PRO

Q96AY2

Pharos - Targets

Q96AY2

HMDB Protein

HMDBP08714

PDB

2ZIX, 4P0R, 2ZIV, 2ZIW, 4P0P, 4P0S, 2ZIU, 4P0Q

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96NY9 MUS81	1	MUS81 [nucleoplasm] (R-HSA-5686443)	0.914	11