Reactome | MUS81 [nucleoplasm]

MUS81 [nucleoplasm]

Stable Identifier

R-HSA-5686443

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Crossover junction endonuclease MUS81

Locations in the PathwayBrowser for interactor UniProt:A4GXA9 EME2

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        MUS81 binds EME1, EME2 (Homo sapiens)
        
        MUS81 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96NY9 MUS81

Gene Names

MUS81

Chain

chain:1-551

Reference Genes

BioGPS Gene:80198 MUS81

COSMIC (genes):MUS81 MUS81

CTD Gene:80198 MUS81

dbSNP Gene:80198 MUS81

ENSEMBL:ENSG00000172732 MUS81

HGNC:29814 MUS81

KEGG:hsa:80198 MUS81

Monarch:80198 MUS81

NCBI Gene:80198 MUS81

OMIM:606591 MUS81

UCSC:Q96NY9 MUS81

Reference Transcript

Other Identifiers

11757637_a_at

16727111

218463_PM_s_at

218463_s_at

3335644

3335646

3335647

3335648

3335649

3335650

3335651

3335652

3335653

3335654

3335655

3335656

3335657

3335658

3335659

3335660

3335661

3335662

3335663

3335664

3335665

3335666

3335667

3335668

3335669

3335670

3335671

3335672

3335673

3335674

3335675

3335676

3335677

3335678

3335679

3335680

3335681

3335682

3335683

3335684

3335685

3335686

3335687

3335688

3335694

3335696

56253_at

7941425

80198

85124_at

A_14_P107000

A_14_P126179

A_23_P161628

A_23_P161634

A_24_P412238

GE62767

GO:0000712

GO:0000727

GO:0003677

GO:0003824

GO:0004518

GO:0004519

GO:0005515

GO:0005634

GO:0005654

GO:0005657

GO:0005730

GO:0006281

GO:0006302

GO:0006308

GO:0006310

GO:0008821

GO:0016787

GO:0022414

GO:0031297

GO:0031573

GO:0033687

GO:0043226

GO:0043596

GO:0046872

GO:0048257

GO:0048476

GO:0072429

GO:0140097

GO:1905347

HMNXSV003018455

HMNXSV003035803

ILMN_1780937

PH_hs_0014997

TC11000644.hg

g13376706_3p_s_at

Participates

as an input of

MUS81 binds EME1, EME2 (Homo sapiens)

as a component of

Inferred To

mus81 [nucleoplasm] (Danio rerio)

mus81 [nucleoplasm] (Schizosaccharomyces pombe)

mus81 [nucleoplasm] (Xenopus tropicalis)

MUS81 [nucleoplasm] (Bos taurus)

MUS81 [nucleoplasm] (Canis familiaris)

MUS81 [nucleoplasm] (Saccharomyces cerevisiae)

MUS81 [nucleoplasm] (Sus scrofa)

Mus81 [nucleoplasm] (Mus musculus)

Mus81 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_079404.3, XP_011543572.1

ENSEMBL

ENST00000308110, ENSP00000307853

OpenTargets

ENSG00000172732

HPA

ENSG00000172732-MUS81

PRO

Q96NY9

Pharos - Targets

Q96NY9

HMDB Protein

HMDBP08764

PDB

4P0R, 9F99, 4P0S, 9F9M, 6VWB, 7BU5, 7F6L, 9F9A, 2MC3, 4P0P, 2ZIX, 4P0Q

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96AY2 EME1	1	EME1 [nucleoplasm] (R-HSA-5686437)	0.914	11
UniProt:Q8IY92 SLX4	1	SLX4 [nucleoplasm] (R-HSA-5686477)	0.845	13
UniProt:P39748 FEN1	1	FEN1 [nucleoplasm] (R-HSA-54745)	0.599	5
UniProt:A4GXA9 EME2	1	EME2 [nucleoplasm] (R-HSA-5686438)	0.544	3
UniProt:Q9Y2L1 DIS3	2	DIS3 [nucleoplasm] (R-HSA-6791517) DIS3 [cytosol] (R-HSA-429935)	0.527	3
UniProt:Q9BQ83 SLX1A	1	SLX1A [nucleoplasm] (R-HSA-5686481)	0.527	2
UniProt:Q92889 ERCC4	1	ERCC4 [nucleoplasm] (R-HSA-67445)	0.527	3