Reactome | MUS81 [nucleoplasm]

MUS81 [nucleoplasm]

Stable Identifier

R-HSA-5686443

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Crossover junction endonuclease MUS81

Locations in the PathwayBrowser for interactor UniProt:Q9BQ83 SLX1A

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        MUS81 binds EME1, EME2 (Homo sapiens)
        
        MUS81 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96NY9 MUS81

Gene Names

MUS81

Chain

chain:1-551

Reference Genes

BioGPS Gene:80198 MUS81

COSMIC (genes):MUS81 MUS81

CTD Gene:80198 MUS81

dbSNP Gene:80198 MUS81

ENSEMBL:ENSG00000172732 MUS81

ENSEMBL_homo_sapiens_GENE:ENSG00000172732.12 MUS81

HGNC:29814 MUS81

KEGG Gene (Homo sapiens):80198 MUS81

Monarch:80198 MUS81

NCBI Gene:80198 MUS81

OMIM:606591 MUS81

UCSC:Q96NY9 MUS81

Reference Transcript

Other Identifiers

11757637_a_at

16727111

218463_PM_s_at

218463_s_at

3335646

3335647

3335648

3335649

3335650

3335652

3335653

3335655

3335656

3335657

3335658

3335659

3335665

3335666

3335667

3335669

3335670

3335673

3335676

3335677

3335679

3335680

3335682

3335683

3335685

3335686

56253_at

7941425

80198

A_14_P126179

A_23_P161628

A_23_P161634

GO:0000228

GO:0000278

GO:0000712

GO:0000727

GO:0003677

GO:0003824

GO:0004518

GO:0004519

GO:0005515

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005730

GO:0006260

GO:0006281

GO:0006302

GO:0006308

GO:0006310

GO:0006974

GO:0007059

GO:0008821

GO:0016787

GO:0022414

GO:0023052

GO:0031297

GO:0031573

GO:0033687

GO:0043226

GO:0043596

GO:0046872

GO:0048257

GO:0048476

GO:0072429

GO:0140013

GO:0140097

GO:1905347

HMNXSV003018455

HMNXSV003035803

ILMN_1780937

PH_hs_0014997

TC11000644.hg

g13376706_3p_s_at

Participates

as an input of

MUS81 binds EME1, EME2 (Homo sapiens)

as a component of

Inferred To

mus81 [nucleoplasm] (Danio rerio)

mus81 [nucleoplasm] (Schizosaccharomyces pombe)

mus81 [nucleoplasm] (Xenopus tropicalis)

MUS81 [nucleoplasm] (Bos taurus)

MUS81 [nucleoplasm] (Canis familiaris)

MUS81 [nucleoplasm] (Saccharomyces cerevisiae)

MUS81 [nucleoplasm] (Sus scrofa)

Mus81 [nucleoplasm] (Mus musculus)

Mus81 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_079404.3, XP_011543572.1

OpenTargets

ENSG00000172732

HPA

ENSG00000172732-MUS81

GeneCards

Q96NY9

Ensembl

ENSG00000172732, ENSP00000307853, ENST00000308110

PRO

Q96NY9

Pharos - Targets

Q96NY9

HMDB Protein

HMDBP08764

PDB

4P0P, 7F6L, 4P0R, 7BU5, 2ZIX, 4P0Q, 2MC3, 4P0S, 6VWB

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96AY2 EME1	1	EME1 [nucleoplasm] (R-HSA-5686437)	0.914	11
UniProt:Q8IY92 SLX4	1	SLX4 [nucleoplasm] (R-HSA-5686477)	0.845	13
UniProt:P39748 FEN1	1	FEN1 [nucleoplasm] (R-HSA-54745)	0.599	5
UniProt:A4GXA9 EME2	1	EME2 [nucleoplasm] (R-HSA-5686438)	0.544	3
UniProt:Q9Y2L1 DIS3	2	DIS3 [nucleoplasm] (R-HSA-6791517) DIS3 [cytosol] (R-HSA-429935)	0.527	3
UniProt:Q9BQ83 SLX1A	1	SLX1A [nucleoplasm] (R-HSA-5686481)	0.527	2
UniProt:Q92889 ERCC4	1	ERCC4 [nucleoplasm] (R-HSA-67445)	0.527	3