Reactome | SLX4 [nucleoplasm]

SLX4 [nucleoplasm]

Stable Identifier

R-HSA-5686477

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Structure-specific endonuclease subunit SLX4, BTB/POZ domain-containing protein 12, BTBD12

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8IY92 SLX4

Gene Names

SLX4, BTBD12, KIAA1784, KIAA1987

Chain

chain:1-1834

Reference Genes

BioGPS Gene:84464 SLX4

COSMIC (genes):SLX4 SLX4

CTD Gene:84464 SLX4

dbSNP Gene:84464 SLX4

ENSEMBL:ENSG00000188827 SLX4

ENSEMBL_homo_sapiens_GENE:ENSG00000188827.12 SLX4

HGNC:23845 SLX4

KEGG Gene (Homo sapiens):84464 SLX4

Monarch:84464 SLX4

NCBI Gene:84464 SLX4

OMIM:613278 SLX4

UCSC:Q8IY92 SLX4

Reference Transcript

RefSeq:NM_032444.3 SLX4

Other Identifiers

11737079_a_at

16823393

232147_PM_at

232147_at

239687_PM_at

239687_at

3677703

3677704

3677705

3677706

3677707

3677710

3677711

3677712

3677713

3677714

3677715

3677716

3677717

3677718

3677719

3677720

3677721

3677722

3677723

3677724

3677725

3677727

3677728

3677730

3677731

3677733

3677734

3677736

3677738

3677739

3677740

3677741

3677742

3677743

54507_at

75453_at

7999008

84464

A_23_P371129

GE84639

GO:0000228

GO:0000712

GO:0000724

GO:0000781

GO:0000785

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006259

GO:0006260

GO:0006281

GO:0006289

GO:0006310

GO:0006974

GO:0006996

GO:0007059

GO:0008047

GO:0010792

GO:0022414

GO:0030054

GO:0032200

GO:0032206

GO:0033557

GO:0043226

GO:0046872

GO:0048476

GO:0061820

GO:0070522

GO:0072429

GO:0090656

GO:0098772

GO:0140013

GO:1904357

GO:1904431

HMNXSV003056608

Hs.143681.0.A1_3p_at

Hs.143681.0.A1_3p_x_at

Hs.98026.0.S1_3p_s_at

ILMN_1732885

PH_hs_0005371

PH_hs_0031801

TC16000821.hg

Participates

as a component of

SLX1A:SLX4 [nucleoplasm] (Homo sapiens)

Inferred To

slx4 [nucleoplasm] (Xenopus tropicalis)

Slx4 [nucleoplasm] (Rattus norvegicus)

SLX4 [nucleoplasm] (Bos taurus)

SLX4 [nucleoplasm] (Canis familiaris)

SLX4 [nucleoplasm] (Gallus gallus)

SLX4 [nucleoplasm] (Mus musculus)

SLX4 [nucleoplasm] (Sus scrofa)

mus312 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_115820.2

OpenTargets

ENSG00000188827

GeneCards

Q8IY92

HPA

ENSG00000188827-SLX4

Ensembl

ENST00000294008, ENSG00000188827, ENSP00000294008

PRO

Q8IY92

Pharos - Targets

Q8IY92

Orphanet

19826

PDB

7TUJ, 4M7C, 7BU5, 4ZOU, 4UYI

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96NY9 MUS81	1	MUS81 [nucleoplasm] (R-HSA-5686443)	0.845	13
UniProt:Q92889 ERCC4	1	ERCC4 [nucleoplasm] (R-HSA-67445)	0.785	11
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.777	8
UniProt:P07992 ERCC1	2	Ub-ERCC1 [nucleoplasm] (R-HSA-5696473) ERCC1 [nucleoplasm] (R-HSA-54427)	0.641	6
UniProt:P43246 MSH2	3	MSH2 R406* [nucleoplasm] (R-HSA-5575594) MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243)	0.567	5
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.527	3

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