Reactome | Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)

Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)

Stable Identifier

R-HSA-5686483

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)

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Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)

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The identity of DNA ligases that ligate DNA strands generated during cleavage of Holliday junctions by GEN1 or the SLX-MUS complex (composed of SLX1A:SLX4 heterodimer and MUS81:EME1 or possibly MUS81:EME2 heterodimer) is not known. The resolvase activity of GEN1 or SLX-MUS predominantly results in the generation of crossover products, with exchange of genetic material between sister chromatids (Wyatt et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
24076221	Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells Wyatt, HD, Sarbajna, S, Matos, J, West, SC	Mol. Cell	2013