Activated ATM phosphorylates ABL1

Stable Identifier
R-HSA-5686578
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ATM, activated in response to DNA damage in the form of double strand breaks, phosphorylates ABL1 (c-ABL) on serine residue S456, resulting in the activation of kinase activity of ABL1 (Baskaran et al. 1997).

Literature References
PubMed ID Title Journal Year
9168116 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

Baskaran, R, Wood, LD, Whitaker, LL, Canman, CE, Morgan, SE, Xu, Y, Barlow, C, Baltimore, D, Wynshaw-Boris, A, Kastan, MB, Wang, JY

Nature 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created